SCOPe 2.01: Domain d2bfmd_: 2bfm D:

Lineage for d2bfmd_ (2bfm D:)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Dihydropteridin reductase (pteridine reductase) [51769] (6 species)

7. Species Leishmania major [TaxId:5664] [63926] (10 PDB entries)
   Uniprot Q01782

8. Domain d2bfmd_: 2bfm D: [128442]
   automated match to d1e7wa_
   complexed with ndp, top

Details for d2bfmd_

PDB Entry: 2bfm, 2.6 Å

PDB Description: leishmania major pteridine reductase 1 in complex with nadp and trimethoprim

PDB Compounds: (D:) pteridine reductase 1

SCOPe Domain Sequences for d2bfmd_:

Sequence, based on SEQRES records:

>d2bfmd_ c.2.1.2 (D:) Dihydropteridin reductase (pteridine reductase) {Leishmania major [TaxId: 5664]}
tvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqa
dlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrnded
ghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamt
nqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweghrsk
vplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

Sequence, based on observed residues (ATOM records):

>d2bfmd_ c.2.1.2 (D:) Dihydropteridin reductase (pteridine reductase) {Leishmania major [TaxId: 5664]}
tvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqa
dlsnvatapapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrreametatadl
fgsnaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakgaleg
ltrsaalelaplqirvngvgpglsvlvghrskvplyqrdssaaevsdvviflcsskakyi
tgtcvkvdggysltra

Timeline for d2bfmd_:

• d2bfmd_ first appeared in SCOP 1.73, called d2bfmd1
  
• d2bfmd_ was called d2bfmd1 in SCOP 1.75
  
• d2bfmd_ appears in SCOPe 2.02
  
• d2bfmd_ appears in the current release, SCOPe 2.08