SCOP 1.73: Domain d2bfmc1: 2bfm C:6-288

Lineage for d2bfmc1 (2bfm C:6-288)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Dihydropteridin reductase (pteridine reductase) [51769] (6 species)

7. Species Leishmania major [TaxId:5664] [63926] (8 PDB entries)

8. Domain d2bfmc1: 2bfm C:6-288 [128441]
   automatically matched to d1e7wa_
   complexed with ndp, top

Details for d2bfmc1

PDB Entry: 2bfm, 2.6 Å

PDB Description: leishmania major pteridine reductase 1 in complex with nadp and trimethoprim

PDB Compounds: (C:) pteridine reductase 1

SCOP Domain Sequences for d2bfmc1:

Sequence, based on SEQRES records:

>d2bfmc1 c.2.1.2 (C:6-288) Dihydropteridin reductase (pteridine reductase) {Leishmania major [TaxId: 5664]}
vpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqad
lsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrndedg
hepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamtn
qpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweghrskv
plyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

Sequence, based on observed residues (ATOM records):

>d2bfmc1 c.2.1.2 (C:6-288) Dihydropteridin reductase (pteridine reductase) {Leishmania major [TaxId: 5664]}
vpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqad
lsnvataapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrreametatadlfg
snaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakgaleglt
rsaalelaplqirvngvgpglsvlvghrskvplyqrdssaaevsdvviflcsskakyitg
tcvkvdggysltra

Timeline for d2bfmc1:

• d2bfmc1 is new in SCOP 1.73
  
• d2bfmc1 appears in SCOP 1.75
  
• d2bfmc1 appears in the current release, SCOPe 2.08, called d2bfmc_