SCOPe 2.01: Domain d2bdfa1: 2bdf A:257-528

Lineage for d2bdfa1 (2bdf A:257-528)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein c-src tyrosine kinase [56155] (2 species)
   PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56156] (8 PDB entries)

8. Domain d2bdfa1: 2bdf A:257-528 [128336]
   automatically matched to d1fmk_3
   complexed with 24a

Details for d2bdfa1

PDB Entry: 2bdf, 2.1 Å

PDB Description: Src kinase in complex with inhibitor AP23451

PDB Compounds: (A:) Proto-oncogene tyrosine-protein kinase Src

SCOPe Domain Sequences for d2bdfa1:

Sequence, based on SEQRES records:

>d2bdfa1 d.144.1.7 (A:257-528) c-src tyrosine kinase {Human (Homo sapiens) [TaxId: 9606]}
kdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvmkk
lrheklvqlyavvseepiyivteymskgslldflkgetgkylrlpqlvdmaaqiasgmay
vermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpikwtapeaaly
grftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmc
qcwrkepeerptfeylqafledyftstepqyq

Sequence, based on observed residues (ATOM records):

>d2bdfa1 d.144.1.7 (A:257-528) c-src tyrosine kinase {Human (Homo sapiens) [TaxId: 9606]}
kdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvmkk
lrheklvqlyavvseepiyivteymskgslldflkgetgkylrlpqlvdmaaqiasgmay
vermnyvhrdlraanilvgenlvckvadfglarliefpikwtapeaalygrftiksdvws
fgilltelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkepeerp
tfeylqafledyftstepqyq

Timeline for d2bdfa1:

• d2bdfa1 first appeared in SCOP 1.73
  
• d2bdfa1 appears in SCOP 1.75
  
• d2bdfa1 appears in SCOPe 2.02
  
• d2bdfa1 appears in the current release, SCOPe 2.08, called d2bdfa_