SCOPe 2.08: Domain d2baja2: 2baj A:2-353

Lineage for d2baja2 (2baj A:2-353)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase p38 [56129] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56130] (204 PDB entries)

8. Domain d2baja2: 2baj A:2-353 [128238]
   Other proteins in same PDB: d2baja3
   automated match to d1a9u__
   complexed with 1pp

Details for d2baja2

PDB Entry: 2baj, 2.25 Å

PDB Description: p38alpha bound to pyrazolourea

PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOPe Domain Sequences for d2baja2:

Sequence, based on SEQRES records:

>d2baja2 d.144.1.7 (A:2-353) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
sqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqs
iihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqk
ltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtg
yvatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgt
pgaellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaq
alahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppl

Sequence, based on observed residues (ATOM records):

>d2baja2 d.144.1.7 (A:2-353) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
sqerptfyrqeliwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlndhvqfliyqi
lrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyvatrwyrapeim
lnnqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkissesrnyi
qsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhdpddepv
adpydqsfesrdllidewksltydevisfvpppl

Timeline for d2baja2:

• d2baja2 first appeared in SCOP 1.73, called d2baja1
  
• d2baja2 appears in SCOPe 2.07