SCOPe 2.08: Domain d2b4ya1: 2b4y A:36-302

Lineage for d2b4ya1 (2b4y A:36-302)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

6. Protein NAD-dependent deacetylase sirtuin-5 [142128] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [142129] (5 PDB entries)
   Uniprot Q9NXA8 36-302

8. Domain d2b4ya1: 2b4y A:36-302 [127868]
   complexed with apr, epe, zn

Details for d2b4ya1

PDB Entry: 2b4y, 1.9 Å

PDB Description: Crystal Structure of Human Sirtuin homolog 5

PDB Compounds: (A:) NAD-dependent deacetylase sirtuin-5

SCOPe Domain Sequences for d2b4ya1:

Sequence, based on SEQRES records:

>d2b4ya1 c.31.1.5 (A:36-302) NAD-dependent deacetylase sirtuin-5 {Human (Homo sapiens) [TaxId: 9606]}
psssmadfrkffakakhiviisgagvsaesgvptfrgaggywrkwqaqdlatplafahnp
srvwefyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhrkagtknll
eihgslfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprceeagcggl
lrphvvwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaargvpvaefn
tettpatnrfrfhfqgpcgttlpeala

Sequence, based on observed residues (ATOM records):

>d2b4ya1 c.31.1.5 (A:36-302) NAD-dependent deacetylase sirtuin-5 {Human (Homo sapiens) [TaxId: 9606]}
psssmadfrkffakakhiviisgagvsaesgvgywrkwqaqdlatplafahnpsrvwefy
hyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhrkagtknlleihgslf
ktrctscgvvaenykspicpalsgkgapepgtqdasipveklprceeagcggllrphvvw
fgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaargvpvaefntettpat
nrfrfhfqgpcgttlpeala

Timeline for d2b4ya1:

• d2b4ya1 first appeared in SCOP 1.73
  
• d2b4ya1 appears in SCOPe 2.07