SCOPe 2.04: Domain d2b3yb1: 2b3y B:631-889

Lineage for d2b3yb1 (2b3y B:631-889)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.8: The "swivelling" beta/beta/alpha domain [52008] (10 superfamilies)
   3 layers: b/b/a; the central sheet is parallel, and the other one is antiparallel; there are some variations in topology
   this domain is thought to be mobile in most multi-domain proteins known to contain it

4. Superfamily c.8.2: LeuD/IlvD-like [52016] (4 families)
   contains mixed beta-sheet barrel, closed n=7, S=10

5. Family c.8.2.1: LeuD-like [52017] (4 proteins)
   Pfam PF00694; permutation of the domain order in the proteins containing this family domain

6. Protein ron-responsive element binding protein 1, C-terminal domain [141974] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [141975] (2 PDB entries)
   Uniprot P21399 631-889

8. Domain d2b3yb1: 2b3y B:631-889 [127805]
   Other proteins in same PDB: d2b3ya2, d2b3yb2
   automated match to d2b3xa1
   complexed with act, fmt, gol, sf4

Details for d2b3yb1

PDB Entry: 2b3y, 1.85 Å

PDB Description: Structure of a monoclinic crystal form of human cytosolic aconitase (IRP1)

PDB Compounds: (B:) Iron-responsive element binding protein 1

SCOPe Domain Sequences for d2b3yb1:

Sequence; same for both SEQRES and ATOM records:

>d2b3yb1 c.8.2.1 (B:631-889) ron-responsive element binding protein 1, C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
dklffwnskstyiksppffenltldlqppksivdayvllnlgdsvttdhispagniarns
paaryltnrgltprefnsygsrrgndavmargtfanirllnrflnkqapqtihlpsgeil
dvfdaaeryqqaglplivlagkeygagssrdwaakgpfllgikavlaesyerihrsnlvg
mgvipleylpgenadalgltgqerytiiipenlkpqmkvqvkldtgktfqavmrfdtdve
ltyflnggilnymirkmak

Timeline for d2b3yb1:

• d2b3yb1 first appeared in SCOP 1.73
  
• d2b3yb1 appears in SCOPe 2.03
  
• d2b3yb1 appears in SCOPe 2.05
  
• d2b3yb1 appears in the current release, SCOPe 2.08