SCOPe 2.03: Domain d2b3ya2: 2b3y A:2-630

Lineage for d2b3ya2 (2b3y A:2-630)

1. Root: SCOPe 2.03

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.83: Aconitase iron-sulfur domain [53731] (1 superfamily)
   consists of three similar domains with 3 layers (a/b/a) each; duplication
   core: parallel beta-sheet of 5 strands, order 32145

4. Superfamily c.83.1: Aconitase iron-sulfur domain [53732] (1 family)

5. Family c.83.1.1: Aconitase iron-sulfur domain [53733] (4 proteins)
   duplication: consists of three structurally similar subdomains with subdomains 1 and 3 being related by pseudo twofold symmetry

6. Protein Iron-responsive element binding protein 1, N-terminal domain [142758] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [142759] (2 PDB entries)
   Uniprot P21399 2-630

8. Domain d2b3ya2: 2b3y A:2-630 [127804]
   Other proteins in same PDB: d2b3ya1, d2b3yb1
   automated match to d2b3xa2
   complexed with act, fmt, gol, sf4

Details for d2b3ya2

PDB Entry: 2b3y, 1.85 Å

PDB Description: Structure of a monoclinic crystal form of human cytosolic aconitase (IRP1)

PDB Compounds: (A:) Iron-responsive element binding protein 1

SCOPe Domain Sequences for d2b3ya2:

Sequence; same for both SEQRES and ATOM records:

>d2b3ya2 c.83.1.1 (A:2-630) Iron-responsive element binding protein 1, N-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
snpfahlaepldpvqpgkkffnlnkledsrygrlpfsirvlleaairncdeflvkkqdie
nilhwnvtqhknievpfkparvilqdftgvpavvdfaamrdavkklggdpekinpvcpad
lvidhsiqvdfnrradslqknqdlefernrerfeflkwgsqafhnmriippgsgiihqvn
leylarvvfdqdgyyypdslvgtdshttmidglgilgwgvggieaeavmlgqpismvlpq
vigyrlmgkphplvtstdivltitkhlrqvgvvgkfveffgpgvaqlsiadratianmcp
eygataaffpvdevsitylvqtgrdeeklkyikkylqavgmfrdfndpsqdpdftqvvel
dlktvvpccsgpkrpqdkvavsdmkkdfesclgakqgfkgfqvapehhndhktfiydnte
ftlahgsvviaaitsctntsnpsvmlgagllakkavdaglnvmpyiktslspgsgvvtyy
lqesgvmpylsqlgfdvvgygcmtcignsgplpepvveaitqgdlvavgvlsgnrnfegr
vhpntranylaspplviayaiagtiridfekeplgvnakgqqvflkdiwptrdeiqaver
qyvipgmfkevyqkietvneswnalatps

Timeline for d2b3ya2:

• d2b3ya2 first appeared in SCOP 1.73
  
• d2b3ya2 appears in SCOPe 2.02
  
• d2b3ya2 appears in SCOPe 2.04
  
• d2b3ya2 appears in the current release, SCOPe 2.08