SCOP 1.73: Domain d2b0ma1: 2b0m A:33-396

Lineage for d2b0ma1 (2b0m A:33-396)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.4: FMN-linked oxidoreductases [51395] (1 family)

5. Family c.1.4.1: FMN-linked oxidoreductases [51396] (18 proteins)

6. Protein Dihydroorotate dehydrogenase [51397] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51400] (8 PDB entries)

8. Domain d2b0ma1: 2b0m A:33-396 [127644]
   automatically matched to d1d3ga_
   complexed with 201, fmn, oro

Details for d2b0ma1

PDB Entry: 2b0m, 2 Å

PDB Description: Human dihydroorotate dehydrogenase bound to a novel inhibitor

PDB Compounds: (A:) Dihydroorotate dehydrogenase, mitochondrial

SCOP Domain Sequences for d2b0ma1:

Sequence, based on SEQRES records:

>d2b0ma1 c.1.4.1 (A:33-396) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
gderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnpv
giaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnsh
glsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvn
vsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvv
kelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiig
vggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaiga
dhrr

Sequence, based on observed residues (ATOM records):

>d2b0ma1 c.1.4.1 (A:33-396) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
gderfyaehlmptlqglldpesahrlavrftslgllpfqdsdmlevrvlghkfrnpvgia
agfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshgls
vvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvss
pntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkel
gidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvgg
vssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhr
r

Timeline for d2b0ma1:

• d2b0ma1 is new in SCOP 1.73
  
• d2b0ma1 appears in SCOP 1.75
  
• d2b0ma1 appears in the current release, SCOPe 2.08, called d2b0ma_