SCOPe 2.07: Domain d2az5d_: 2az5 D:

Lineage for d2az5d_ (2az5 D:)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.22: TNF-like [49841] (1 superfamily)
   sandwich, 10 strands in 2 sheets; jelly-roll

4. Superfamily b.22.1: TNF-like [49842] (2 families)

5. Family b.22.1.1: TNF-like [49843] (15 proteins)

6. Protein Tumor necrosis factor (TNF) [49848] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49849] (33 PDB entries)

8. Domain d2az5d_: 2az5 D: [127602]
   automated match to d1tnfa_
   complexed with 307

Details for d2az5d_

PDB Entry: 2az5, 2.1 Å

PDB Description: crystal structure of tnf-alpha with a small molecule inhibitor

PDB Compounds: (D:) Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

SCOPe Domain Sequences for d2az5d_:

Sequence, based on SEQRES records:

>d2az5d_ b.22.1.1 (D:) Tumor necrosis factor (TNF) {Human (Homo sapiens) [TaxId: 9606]}
dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
psthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfqlekg
drlsaeinrpdyldfaesgqvyfgiial

Sequence, based on observed residues (ATOM records):

>d2az5d_ b.22.1.1 (D:) Tumor necrosis factor (TNF) {Human (Homo sapiens) [TaxId: 9606]}
dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
psthvllthtisriavsyqtkvnllsaikspcqrakpwyepiylggvfqlekgdrlsaei
nrpdyldfaesgqvyfgiial

Timeline for d2az5d_:

• d2az5d_ first appeared in SCOP 1.73, called d2az5d1
  
• d2az5d_ appears in SCOPe 2.06
  
• d2az5d_ appears in the current release, SCOPe 2.08