SCOP 1.73: Domain d2az5b1: 2az5 B:10-157

Lineage for d2az5b1 (2az5 B:10-157)

1. Root: SCOP 1.73

2. Class b: All beta proteins [48724] (165 folds)

3. Fold b.22: TNF-like [49841] (1 superfamily)
   sandwich, 10 strands in 2 sheets; jelly-roll

4. Superfamily b.22.1: TNF-like [49842] (1 family)

5. Family b.22.1.1: TNF-like [49843] (13 proteins)

6. Protein Tumor necrosis factor (TNF) [49848] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49849] (7 PDB entries)

8. Domain d2az5b1: 2az5 B:10-157 [127600]
   automatically matched to d1tnfa_
   complexed with 307

Details for d2az5b1

PDB Entry: 2az5, 2.1 Å

PDB Description: crystal structure of tnf-alpha with a small molecule inhibitor

PDB Compounds: (B:) Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

SCOP Domain Sequences for d2az5b1:

Sequence, based on SEQRES records:

>d2az5b1 b.22.1.1 (B:10-157) Tumor necrosis factor (TNF) {Human (Homo sapiens) [TaxId: 9606]}
dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
psthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfqlekg
drlsaeinrpdyldfaesgqvyfgiial

Sequence, based on observed residues (ATOM records):

>d2az5b1 b.22.1.1 (B:10-157) Tumor necrosis factor (TNF) {Human (Homo sapiens) [TaxId: 9606]}
dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
psthvllthtisriavsyqtkvnllsaikspcqrkpwyepiylggvfqlekgdrlsaein
rpdyldfaesgqvyfgiial

Timeline for d2az5b1:

• d2az5b1 is new in SCOP 1.73
  
• d2az5b1 appears in SCOP 1.75
  
• d2az5b1 appears in the current release, SCOPe 2.08, called d2az5b_