SCOPe 2.08: Domain d2ax6a_: 2ax6 A:

Lineage for d2ax6a_ (2ax6 A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Androgen receptor [63621] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63623] (65 PDB entries)
   Uniprot P10275 671-919

8. Domain d2ax6a_: 2ax6 A: [127479]
   automated match to d1e3ga_
   complexed with hft; mutant

Details for d2ax6a_

PDB Entry: 2ax6, 1.5 Å

PDB Description: crystal structure of the androgen receptor ligand binding domain t877a mutant in complex with hydroxyflutamide

PDB Compounds: (A:) Androgen receptor

SCOPe Domain Sequences for d2ax6a_:

Sequence, based on SEQRES records:

>d2ax6a_ a.123.1.1 (A:) Androgen receptor {Human (Homo sapiens) [TaxId: 9606]}
piflnvleaiepgvvcaghdnnqpdsfaallsslnelgerqlvhvvkwakalpgfrnlhv
ddqmaviqyswmglmvfamgwrsftnvnsrmlyfapdlvfneyrmhksrmysqcvrmrhl
sqefgwlqitpqeflcmkalllfsiipvdglknqkffdelrmnyikeldriiackrknpt
scsrrfyqltklldsvqpiarelhqfafdllikshmvsvdfpemmaeiisvqvpkilsgk
vkpiyfh

Sequence, based on observed residues (ATOM records):

>d2ax6a_ a.123.1.1 (A:) Androgen receptor {Human (Homo sapiens) [TaxId: 9606]}
piflnvleaiepgvvcaghdnnqpdsfaallsslnelgerqlvhvvkwakalpgfrnlhv
ddqmaviqyswmglmvfamgwrsftnvnsrmlyfapdlvfneyrmhksrmysqcvrmrhl
sqefgwlqitpqeflcmkalllfsiipvdglknqkffdelrmnyikeldriiaptscsrr
fyqltklldsvqpiarelhqfafdllikshmvsvdfpemmaeiisvqvpkilsgkvkpiy
fh

Timeline for d2ax6a_:

• d2ax6a_ first appeared in SCOP 1.73, called d2ax6a1
  
• d2ax6a_ appears in SCOPe 2.07