SCOPe 2.07: Domain d2aovb_: 2aov B:

Lineage for d2aovb_ (2aov B:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (60 families)

5. Family c.66.1.19: Histamine methyltransferase [75261] (1 protein)

6. Protein Histamine methyltransferase [75262] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [75263] (7 PDB entries)

8. Domain d2aovb_: 2aov B: [127103]
   automated match to d1jqda_
   complexed with 4di, c2m

Details for d2aovb_

PDB Entry: 2aov, 2.48 Å

PDB Description: Histamine Methyltransferase Complexed with the Antifolate Drug Metoprine

PDB Compounds: (B:) Histamine N-methyltransferase

SCOPe Domain Sequences for d2aovb_:

Sequence; same for both SEQRES and ATOM records:

>d2aovb_ c.66.1.19 (B:) Histamine methyltransferase {Human (Homo sapiens) [TaxId: 9606]}
mrslfsdhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsigggag
eidlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhketsseyq
srmlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwdklwk
kygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdllwdfl
tetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea

Timeline for d2aovb_:

• d2aovb_ first appeared in SCOP 1.73, called d2aovb1
  
• d2aovb_ appears in SCOPe 2.06
  
• d2aovb_ appears in the current release, SCOPe 2.08