SCOPe 2.08: Domain d2aota_: 2aot A:

Lineage for d2aota_ (2aot A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (61 families)

5. Family c.66.1.19: Histamine methyltransferase [75261] (1 protein)

6. Protein Histamine methyltransferase [75262] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [75263] (7 PDB entries)

8. Domain d2aota_: 2aot A: [127098]
   automated match to d1jqda_
   complexed with 2pm, sah

Details for d2aota_

PDB Entry: 2aot, 1.9 Å

PDB Description: Histamine Methyltransferase Complexed with the Antihistamine Drug Diphenhydramine

PDB Compounds: (A:) Histamine N-methyltransferase

SCOPe Domain Sequences for d2aota_:

Sequence; same for both SEQRES and ATOM records:

>d2aota_ c.66.1.19 (A:) Histamine methyltransferase {Human (Homo sapiens) [TaxId: 9606]}
mrslfsdhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsigggag
eidlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhketsseyq
srmlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwdklwk
kygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdllwdfl
tetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea

Timeline for d2aota_:

• d2aota_ first appeared in SCOP 1.73, called d2aota1
  
• d2aota_ appears in SCOPe 2.07