SCOPe 2.06: Domain d2aobd_: 2aob D:

Lineage for d2aobd_ (2aob D:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.93: SH2-like [55549] (1 superfamily)
   3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flanked by two helices

4. Superfamily d.93.1: SH2 domain [55550] (2 families)

5. Family d.93.1.1: SH2 domain [55551] (35 proteins)
   Pfam PF00017

6. Protein Growth factor receptor-bound protein 2 (GRB2) [55563] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55564] (35 PDB entries)

8. Domain d2aobd_: 2aob D: [127079]
   automated match to d1fhs__
   complexed with s1s

Details for d2aobd_

PDB Entry: 2aob, 1.8 Å

PDB Description: crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the grb2 sh2 domain

PDB Compounds: (D:) Growth factor receptor-bound protein 2

SCOPe Domain Sequences for d2aobd_:

Sequence; same for both SEQRES and ATOM records:

>d2aobd_ d.93.1.1 (D:) Growth factor receptor-bound protein 2 (GRB2) {Human (Homo sapiens) [TaxId: 9606]}
pwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvlrdgagky
flwvvkfnslnelvdyhrstsvsrnqqiflrdi

Timeline for d2aobd_:

• d2aobd_ first appeared in SCOP 1.73, called d2aobd1
  
• d2aobd_ appears in SCOPe 2.05
  
• d2aobd_ appears in SCOPe 2.07
  
• d2aobd_ appears in the current release, SCOPe 2.08