SCOPe 2.01: Domain d2ajfa_: 2ajf A:

Lineage for d2ajfa_ (2ajf A:)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families)

5. Family d.92.1.5: Neurolysin-like [55505] (5 proteins)
   combines M2, M3 and M32 families of metalloproteases
   the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain

6. Protein Angiotensin converting enzyme 2, ACE2 [103125] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [103126] (3 PDB entries)

8. Domain d2ajfa_: 2ajf A: [126882]
   Other proteins in same PDB: d2ajfe1, d2ajff_
   automated match to d1r42a_
   complexed with cl, nag, zn

Details for d2ajfa_

PDB Entry: 2ajf, 2.9 Å

PDB Description: structure of sars coronavirus spike receptor-binding domain complexed with its receptor

PDB Compounds: (A:) Angiotensin-converting enzyme-Related Carboxypeptidase (Ace2)

SCOPe Domain Sequences for d2ajfa_:

Sequence; same for both SEQRES and ATOM records:

>d2ajfa_ d.92.1.5 (A:) Angiotensin converting enzyme 2, ACE2 {Human (Homo sapiens) [TaxId: 9606]}
stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqst
laqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnp
qeclllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyed
ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyisp
igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsv
glpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemgh
iqydmayaaqpfllrnganegfheavgeimslsaatpkhlksigllspdfqedneteinf
llkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetyc
dpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnml
rlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyad

Timeline for d2ajfa_:

• d2ajfa_ first appeared in SCOP 1.73, called d2ajfa1
  
• d2ajfa_ was called d2ajfa1 in SCOP 1.75
  
• d2ajfa_ appears in SCOPe 2.02
  
• d2ajfa_ appears in the current release, SCOPe 2.08