SCOPe 2.01: Domain d2ag5a1: 2ag5 A:1-245

Lineage for d2ag5a1 (2ag5 A:1-245)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Dehydrogenase/reductase SDR family member 6, DHRS6 [141894] (1 species)
   Oxidoreductase UCPA

7. Species Human (Homo sapiens) [TaxId:9606] [141895] (1 PDB entry)
   Uniprot Q9BUT1 1-245

8. Domain d2ag5a1: 2ag5 A:1-245 [126719]
   Other proteins in same PDB: d2ag5b_, d2ag5c_, d2ag5d_
   complexed with nad, so4

Details for d2ag5a1

PDB Entry: 2ag5, 1.84 Å

PDB Description: Crystal Structure of Human DHRS6

PDB Compounds: (A:) dehydrogenase/reductase (SDR family) member 6

SCOPe Domain Sequences for d2ag5a1:

Sequence; same for both SEQRES and ATOM records:

>d2ag5a1 c.2.1.2 (A:1-245) Dehydrogenase/reductase SDR family member 6, DHRS6 {Human (Homo sapiens) [TaxId: 9606]}
mgrldgkviiltaaaqgigqaaalafaregakviatdinesklqelekypgiqtrvldvt
kkkqidqfaneverldvlfnvagfvhhgtvldceekdwdfsmnlnvrsmylmikaflpkm
laqksgniinmssvassvkgvvnrcvysttkaavigltksvaadfiqqgircncvcpgtv
dtpslqeriqargnpeearndflkrqktgrfataeeiamlcvylasdesayvtgnpviid
ggwsl

Timeline for d2ag5a1:

• d2ag5a1 first appeared in SCOP 1.73
  
• d2ag5a1 appears in SCOP 1.75
  
• d2ag5a1 appears in SCOPe 2.02
  
• d2ag5a1 appears in the current release, SCOPe 2.08