SCOP 1.73: Domain d2afwb1: 2afw B:33-361

Lineage for d2afwb1 (2afw B:33-361)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.56: Phosphorylase/hydrolase-like [53162] (7 superfamilies)
   core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops

4. Superfamily c.56.5: Zn-dependent exopeptidases [53187] (8 families)
   core: mixed beta-sheet of 8 strands, order 12435867; strands 2, 6 & 7 are antiparallel to the rest

5. Family c.56.5.8: Glutaminyl-peptide cyclotransferase-like [142532] (1 protein)
   part of Pfam PF04389

6. Protein Glutaminyl-peptide cyclotransferase, QPCT [142533] (1 species)
   Glutaminyl cyclase

7. Species Human (Homo sapiens) [TaxId:9606] [142534] (7 PDB entries)

8. Domain d2afwb1: 2afw B:33-361 [126708]
   automatically matched to 2AFM A:33-361
   complexed with ahn, so4, zn

Details for d2afwb1

PDB Entry: 2afw, 1.56 Å

PDB Description: Crystal structure of human glutaminyl cyclase in complex with N-acetylhistamine

PDB Compounds: (B:) Glutaminyl-peptide cyclotransferase

SCOP Domain Sequences for d2afwb1:

Sequence, based on SEQRES records:

>d2afwb1 c.56.5.8 (B:33-361) Glutaminyl-peptide cyclotransferase, QPCT {Human (Homo sapiens) [TaxId: 9606]}
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpygyrsfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdsavpcammlelaraldkkllslktvsdskpdlslqliffdgeeaflhwspqds
lygsrhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlq
aiehelhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtm
ddneenldestidnlnkilqvfvleylhl

Sequence, based on observed residues (ATOM records):

>d2afwb1 c.56.5.8 (B:33-361) Glutaminyl-peptide cyclotransferase, QPCT {Human (Homo sapiens) [TaxId: 9606]}
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpygyrsfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdsavpcammlelaraldkkllslkpdlslqliffdgeeaflhwspqdslygsrh
laakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlqaiehel
helgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtmddneen
ldestidnlnkilqvfvleylhl

Timeline for d2afwb1:

• d2afwb1 is new in SCOP 1.73
  
• d2afwb1 appears in SCOP 1.75
  
• d2afwb1 appears in the current release, SCOPe 2.08, called d2afwb_