SCOPe 2.08: Domain d2a7qa_: 2a7q A:

Lineage for d2a7qa_ (2a7q A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.1: Nucleotide and nucleoside kinases [52541] (21 proteins)
   parallel beta-sheet of 5 strands, order 23145

6. Protein Deoxycytidine kinase [89657] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89658] (45 PDB entries)

8. Domain d2a7qa_: 2a7q A: [126352]
   automated match to d1p5zb_
   complexed with adp, cfb, mg
   has additional insertions and/or extensions that are not grouped together

Details for d2a7qa_

PDB Entry: 2a7q, 2.55 Å

PDB Description: Crystal structure of human dCK complexed with clofarabine and ADP

PDB Compounds: (A:) Deoxycytidine kinase

SCOPe Domain Sequences for d2a7qa_:

Sequence, based on SEQRES records:

>d2a7qa_ c.37.1.1 (A:) Deoxycytidine kinase {Human (Homo sapiens) [TaxId: 9606]}
rikkisiegniaagkstfvnilkqlcedwevvpepvarwcnvqstqdefeeltmsqkngg
nvlqmmyekperwsftfqtyaclsriraqlaslngklkdaekpvlffersvysdryifas
nlyesecmnetewtiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqg
ipleyleklhykheswllhrtlktnfdylqevpiltldvnedfkdkyeslvekvkeflst
l

Sequence, based on observed residues (ATOM records):

>d2a7qa_ c.37.1.1 (A:) Deoxycytidine kinase {Human (Homo sapiens) [TaxId: 9606]}
rikkisiegniaagkstfvnilkqlcedwevvpepvarwcnvqstnggnvlqmmyekper
wsftfqtyaclsriraqlaslngklkdaekpvlffersvysdryifasnlyesecmnete
wtiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhyk
heswllhrtlktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

Timeline for d2a7qa_:

• d2a7qa_ first appeared in SCOP 1.73, called d2a7qa1
  
• d2a7qa_ appears in SCOPe 2.07