SCOPe 2.01: Domain d1zxlb1: 1zxl B:97-425

Lineage for d1zxlb1 (1zxl B:97-425)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Enoyl-ACP reductase [51791] (10 species)

7. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [82296] (23 PDB entries)
   Uniprot Q9BJJ9 96-424 # fragment

8. Domain d1zxlb1: 1zxl B:97-425 [125783]
   automatically matched to 1VRW A:97-425
   complexed with jp1, nad

Details for d1zxlb1

PDB Entry: 1zxl, 3 Å

PDB Description: synthesis, biological activity, and x-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acp reductase. part 1:4'-substituted triclosan derivatives

PDB Compounds: (B:) enoyl-acyl carrier reductase

SCOPe Domain Sequences for d1zxlb1:

Sequence, based on SEQRES records:

>d1zxlb1 c.2.1.2 (B:97-425) Enoyl-ACP reductase {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
edicfiagigdtngygwgiakelskrnvkiifgiwppvynifmknykngkfdndmiidkd
kkmnildmlpfdasfdtandideetknnkrynmlqnytiedvanlihqkygkinmlvhsl
anakevqkdllntsrkgyldalskssyslislckyfvnimkpqssiisltyhasqkvvpg
ygggmssakaalesdtrvlayhlgrnynirintisagplksraatainklnntyenntnq
nknrnshdvhnimnnsgekeekknsasqnytfidyaieysekyaplrqkllstdigsvas
fllsresraitgqtiyvdnglnimflpdd

Sequence, based on observed residues (ATOM records):

>d1zxlb1 c.2.1.2 (B:97-425) Enoyl-ACP reductase {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
edicfiagigdtngygwgiakelskrnvkiifgiwppvynifmknykngkfdndmiidkd
kkmnildmlpfdasfdtandideetknnkrynmlqnytiedvanlihqkygkinmlvhsl
anakevqkdllntsrkgyldalskssyslislckyfvnimkpqssiisltyhasqkvvpg
ygggmssakaalesdtrvlayhlgrnynirintisagplksraatainytfidyaieyse
kyaplrqkllstdigsvasfllsresraitgqtiyvdnglnimflpdd

Timeline for d1zxlb1:

• d1zxlb1 first appeared in SCOP 1.73
  
• d1zxlb1 appears in SCOP 1.75
  
• d1zxlb1 appears in SCOPe 2.02
  
• d1zxlb1 appears in the current release, SCOPe 2.08, called d1zxlb_