Lineage for d1zxla1 (1zxl A:97-425)

  1. Root: SCOP 1.73
  2. 681097Class c: Alpha and beta proteins (a/b) [51349] (141 folds)
  3. 685975Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 685976Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families) (S)
  5. 686289Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 686655Protein Enoyl-ACP reductase [51791] (6 species)
  7. 686702Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [82296] (11 PDB entries)
  8. 686723Domain d1zxla1: 1zxl A:97-425 [125782]
    automatically matched to 1VRW A:97-425
    complexed with jp1, nad

Details for d1zxla1

PDB Entry: 1zxl (more details), 3 Å

PDB Description: Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. Part 1:4'-Substituted Triclosan Derivatives
PDB Compounds: (A:) enoyl-acyl carrier reductase

SCOP Domain Sequences for d1zxla1:

Sequence, based on SEQRES records: (download)

>d1zxla1 c.2.1.2 (A:97-425) Enoyl-ACP reductase {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
edicfiagigdtngygwgiakelskrnvkiifgiwppvynifmknykngkfdndmiidkd
kkmnildmlpfdasfdtandideetknnkrynmlqnytiedvanlihqkygkinmlvhsl
anakevqkdllntsrkgyldalskssyslislckyfvnimkpqssiisltyhasqkvvpg
ygggmssakaalesdtrvlayhlgrnynirintisagplksraatainklnntyenntnq
nknrnshdvhnimnnsgekeekknsasqnytfidyaieysekyaplrqkllstdigsvas
fllsresraitgqtiyvdnglnimflpdd

Sequence, based on observed residues (ATOM records): (download)

>d1zxla1 c.2.1.2 (A:97-425) Enoyl-ACP reductase {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
edicfiagigdtngygwgiakelskrnvkiifgiwppvynifmknykngkfdndmiidkd
kkmnildmlpfdasfdtandideetknnkrynmlqnytiedvanlihqkygkinmlvhsl
anakevqkdllntsrkgyldalskssyslislckyfvnimkpqssiisltyhasqkvvpg
ygggmssakaalesdtrvlayhlgrnynirintisagplksraatainytfidyaieyse
kyaplrqkllstdigsvasfllsresraitgqtiyvdnglnimflpdd

SCOP Domain Coordinates for d1zxla1:

Click to download the PDB-style file with coordinates for d1zxla1.
(The format of our PDB-style files is described here.)

Timeline for d1zxla1: