SCOPe 2.01: Domain d1zj7a_: 1zj7 A:

Lineage for d1zj7a_ (1zj7 A:)

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.1: Retroviral protease (retropepsin) [50631] (9 proteins)
   dimer of identical mono-domain chains, each containing (6,10) barrel

6. Protein Human immunodeficiency virus type 1 protease [50632] (5 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [50633] (378 PDB entries)
   Uniprot P35963 57-155 ! Uniprot P04587 69-167 ! Uniprot P03366 69-167 ! Uniprot P03367 69-167 ! Uniprot P03368 69-167

8. Domain d1zj7a_: 1zj7 A: [125146]
   automated match to d1lzqa_
   complexed with 0zt; mutant

Details for d1zj7a_

PDB Entry: 1zj7, 1.93 Å

PDB Description: crystal structure of a complex of mutant hiv-1 protease (a71v, v82t, i84v) with a hydroxyethylamine peptidomimetic inhibitor boc-phe- psi[s-ch(oh)ch2nh]-phe-glu-phe-nh2

PDB Compounds: (A:) protease retropepsin

SCOPe Domain Sequences for d1zj7a_:

Sequence; same for both SEQRES and ATOM records:

>d1zj7a_ b.50.1.1 (A:) Human immunodeficiency virus type 1 protease {Human immunodeficiency virus type 1 [TaxId: 11676]}
pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
qilieicghkvigtvlvgptptnvigrnlltqigctlnf

Timeline for d1zj7a_:

• d1zj7a_ first appeared in SCOP 1.73, called d1zj7a1
  
• d1zj7a_ was called d1zj7a1 in SCOP 1.75
  
• d1zj7a_ appears in SCOPe 2.02
  
• d1zj7a_ appears in the current release, SCOPe 2.08