SCOPe 2.02: Domain d1z92a_: 1z92 A:

Lineage for d1z92a_ (1z92 A:)

1. Root: SCOPe 2.02

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.2: Short-chain cytokines [47286] (14 proteins)

6. Protein Interleukin-2 (IL-2) [47301] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47302] (15 PDB entries)

8. Domain d1z92a_: 1z92 A: [124737]
   Other proteins in same PDB: d1z92b1, d1z92b2
   automated match to d1irl__

Details for d1z92a_

PDB Entry: 1z92, 2.8 Å

PDB Description: structure of interleukin-2 with its alpha receptor

PDB Compounds: (A:) interleukin-2

SCOPe Domain Sequences for d1z92a_:

Sequence, based on SEQRES records:

>d1z92a_ a.26.1.2 (A:) Interleukin-2 (IL-2) {Human (Homo sapiens) [TaxId: 9606]}
stkktqlqlehllldlqmilnginnyknpkltrmltfkfympkkatelkhlqcleeelkp
leevlnlaqsknfhlrprdlisninvivlelkgsettfmceyadetativeflnrwitfc
qsiistlt

Sequence, based on observed residues (ATOM records):

>d1z92a_ a.26.1.2 (A:) Interleukin-2 (IL-2) {Human (Homo sapiens) [TaxId: 9606]}
stkktqlqlehllldlqmilnginnyknpkltrmltfkfympkkatelkhlqcleeelkp
leevlnlarprdlisninvivlelkgsettfmceyadetativeflnrwitfcqsiistl
t

Timeline for d1z92a_:

• d1z92a_ first appeared in SCOP 1.73, called d1z92a1
  
• d1z92a_ appears in SCOPe 2.01
  
• d1z92a_ appears in SCOPe 2.03
  
• d1z92a_ appears in the current release, SCOPe 2.08