SCOP 1.75: Domain d1z75a1: 1z75 A:315-656

Lineage for d1z75a1 (1z75 A:315-656)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Polymyxin resistance protein ArnA (PrmI) [117419] (1 species)
   evolved new activities: UDP-glucuronic acid decarboxylase, UDP-4-amino-4-deoxy-L-arabinose formyltransferase

7. Species Escherichia coli [TaxId:562] [117420] (7 PDB entries)
   Uniprot P77398

8. Domain d1z75a1: 1z75 A:315-656 [124587]
   complexed with gol, so4; mutant

Details for d1z75a1

PDB Entry: 1z75, 2.4 Å

PDB Description: crystal structure of arna dehydrogenase (decarboxylase) domain, r619m mutant

PDB Compounds: (A:) protein ArnA

SCOP Domain Sequences for d1z75a1:

Sequence, based on SEQRES records:

>d1z75a1 c.2.1.2 (A:315-656) Polymyxin resistance protein ArnA (PrmI) {Escherichia coli [TaxId: 562]}
rtrvlilgvngfignhlterllredhyevygldigsdaisrflnhphfhfvegdisihse
wieyhvkkcdvvlplvaiatpieytrnplrvfeldfeenlriirycvkyrkriifpstse
vygmcsdkyfdedhsnlivgpvnkprwiysvskqlldrviwaygekeglqftlfrpfnwm
gprldnlnaarigssraitqlilnlvegspiklidggkqkrcftdirdgiealyriiena
gnrcdgeiinignpeneasieelgemllasfekhplrhhfppfagfrvvesssyygkgyq
dvehmkpsirnahrcldwepkidmqetidetldfflrtvdlt

Sequence, based on observed residues (ATOM records):

>d1z75a1 c.2.1.2 (A:315-656) Polymyxin resistance protein ArnA (PrmI) {Escherichia coli [TaxId: 562]}
rtrvlilgvngfignhlterllredhyevygldigsdaisrflnhphfhfvegdisihse
wieyhvkkcdvvlplvaiatpieytrnplrvfeldfeenlriirycvkyrkriifpstse
vygmcsdkyfdedhsnlivgpvnkprwiysvskqlldrviwaygekeglqftlfrpfnwm
gprldnlnaarigssraitqlilnlvegspiklidggkqkrcftdirdgiealyriiena
gnrcdgeiinignpeneasieelgemllasfekhplrhhfppfagfrvvesqdvehmkps
irnahrcldwepkidmqetidetldfflrtvdlt

Timeline for d1z75a1:

• d1z75a1 first appeared in SCOP 1.73
  
• d1z75a1 appears in SCOPe 2.01
  
• d1z75a1 appears in the current release, SCOPe 2.08