SCOPe 2.06: Domain d1z6ea_: 1z6e A:

Lineage for d1z6ea_ (1z6e A:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein automated matches [190044] (14 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187233] (146 PDB entries)

8. Domain d1z6ea_: 1z6e A: [124518]
   Other proteins in same PDB: d1z6el_
   automated match to d1c5md_
   complexed with ik8

Details for d1z6ea_

PDB Entry: 1z6e, 1.8 Å

PDB Description: Factor XA in complex with the inhibitor 1-(3'-amino-1,2-benzisoxazol-5'-yl)-n-(4-(2'-((dimethylamino)methyl)-1h-imidazol-1-yl)-2-fluorophenyl)-3-(trifluoromethyl)-1h-pyrazole-5-carboxamide (razaxaban; DPC906; BMS-561389)

PDB Compounds: (A:) coagulation factor x

SCOPe Domain Sequences for d1z6ea_:

Sequence; same for both SEQRES and ATOM records:

>d1z6ea_ b.47.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmkt

Timeline for d1z6ea_:

• d1z6ea_ first appeared in SCOP 1.73, called d1z6ea1
  
• d1z6ea_ appears in SCOPe 2.05
  
• d1z6ea_ appears in SCOPe 2.07
  
• d1z6ea_ appears in the current release, SCOPe 2.08