SCOPe 2.05: Domain d1z5ma_: 1z5m A:

Lineage for d1z5ma_ (1z5m A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein 3-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
   AGC group; PBK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [90037] (25 PDB entries)
   Uniprot O15530 75-363

8. Domain d1z5ma_: 1z5m A: [124486]
   automated match to d1h1wa_
   complexed with cl, gol, li8, so4

Details for d1z5ma_

PDB Entry: 1z5m, 2.17 Å

PDB Description: crystal structure of n1-[3-[[5-bromo-2-[[3-[(1-pyrrolidinylcarbonyl) amino]phenyl]amino]-4-pyrimidinyl]amino]propyl]-2,2- dimethylpropanediamide complexed with human pdk1

PDB Compounds: (A:) 3-phosphoinositide dependent protein kinase-1

SCOPe Domain Sequences for d1z5ma_:

Sequence, based on SEQRES records:

>d1z5ma_ d.144.1.7 (A:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
prkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdv
msrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsal
eylhgkgiihrdlkpenillnedmhiqitdfgtakvlspeskqaransfvgtaqyvspel
lteksackssdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlv
ekllvldatkrlgceemegygplkahpffesvtwenlhqqtppklt

Sequence, based on observed residues (ATOM records):

>d1z5ma_ d.144.1.7 (A:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
prkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdv
msrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsal
eylhgkgiihrdlkpenillnedmhiqitdfgtakvlsfvgtaqyvspellteksackss
dlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlvekllvldatk
rlgceemegygplkahpffesvtwenlhqqtppklt

Timeline for d1z5ma_:

• d1z5ma_ first appeared in SCOP 1.73, called d1z5ma1
  
• d1z5ma_ appears in SCOPe 2.04
  
• d1z5ma_ appears in SCOPe 2.06
  
• d1z5ma_ appears in the current release, SCOPe 2.08