SCOPe 2.02: Domain d1ywna_: 1ywn A:

Lineage for d1ywna_ (1ywn A:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Vascular endothelial growth factor receptor 2 (kdr) [56160] (1 species)
   PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56161] (20 PDB entries)

8. Domain d1ywna_: 1ywn A: [124161]
   automated match to d1vr2a_
   complexed with lif

Details for d1ywna_

PDB Entry: 1ywn, 1.71 Å

PDB Description: vegfr2 in complex with a novel 4-amino-furo[2,3-d]pyrimidine

PDB Compounds: (A:) Vascular endothelial growth factor receptor 2

SCOPe Domain Sequences for d1ywna_:

Sequence, based on SEQRES records:

>d1ywna_ d.144.1.7 (A:) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
lpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkegathseh
ralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnefvpyk
vapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfgl
ardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgaspypgv
kideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllqanaq
qd

Sequence, based on observed residues (ATOM records):

>d1ywna_ d.144.1.7 (A:) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
lpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlthsehralm
selkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnefvpfltleh
licysfqvakgmeflasrkcihrdlaarnillseknvvkicdiykdpdyvrkgdarlplk
wmapetifdrvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdy
ttpemyqtmldcwhgepsqrptfselvehlgnllqanaqqd

Timeline for d1ywna_:

• d1ywna_ first appeared in SCOP 1.73, called d1ywna1
  
• d1ywna_ appears in SCOPe 2.01
  
• d1ywna_ appears in SCOPe 2.03
  
• d1ywna_ appears in the current release, SCOPe 2.08