SCOPe 2.08: Domain d1ysza_: 1ysz A:

Lineage for d1ysza_ (1ysz A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families)

5. Family d.122.1.1: Heat shock protein 90, HSP90, N-terminal domain [55875] (2 proteins)

6. Protein HSP90 [55876] (3 species)

7. Species Dog (Canis familiaris) [TaxId:9615] [103225] (33 PDB entries)
   Uniprot P41148 76-285; Endoplasmin, GRP94

8. Domain d1ysza_: 1ysz A: [123987]
   automated match to d1u2oa_
   complexed with nec, pg4

Details for d1ysza_

PDB Entry: 1ysz, 2.65 Å

PDB Description: crystal structure of the unliganded form of grp94, the er hsp90: basis for nucleotide-induced conformational change, grp94n(delta)41 apo crystal soaked with neca

PDB Compounds: (A:) Endoplasmin

SCOPe Domain Sequences for d1ysza_:

Sequence, based on SEQRES records:

>d1ysza_ d.122.1.1 (A:) HSP90 {Dog (Canis familiaris) [TaxId: 9615]}
ekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenalagneelt
vkikcdkeknllhvtdtgvgmtreelvknlgtiaksgtseflnkmteaqedgqstselig
qfgvgfysaflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgttitlvlke
easdyleldtiknlvkkysqfinfpiyvwssktggggktvwdwelmn

Sequence, based on observed residues (ATOM records):

>d1ysza_ d.122.1.1 (A:) HSP90 {Dog (Canis familiaris) [TaxId: 9615]}
ekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenalagneelt
vkikcdkeknllhvtdtgvgmtreelvknlgtigtseflnkmteaqestseligqfgvgf
ysaflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgttitlvlkeeasdyl
eldtiknlvkkysqfinfpiyvwssktktvwdwelmn

Timeline for d1ysza_:

• d1ysza_ first appeared in SCOP 1.73, called d1ysza1
  
• d1ysza_ appears in SCOPe 2.07