Lineage for d1yovc_ (1yov C:)

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2921020Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest
  4. 2921021Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (3 families) (S)
    transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
    the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds
  5. 2921028Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (3 proteins)
    the common fold is elaborated with additional (sub)domains
  6. 2921029Protein Amyloid beta precursor protein-binding protein 1, APPBP1 [89766] (1 species)
    a subunit of the heterodimeric E1 enzyme for NEDD8; contains a large insertion (residues 170-487) that can be divided into 3 units similar to the UBA3 insertion
  7. 2921030Species Human (Homo sapiens) [TaxId:9606] [89767] (10 PDB entries)
    Uniprot Q13564
  8. 2921034Domain d1yovc_: 1yov C: [123787]
    Other proteins in same PDB: d1yovb_, d1yovd_
    automated match to d1tt5a_
    complexed with zn

    has additional subdomain(s) that are not in the common domain

Details for d1yovc_

PDB Entry: 1yov (more details), 2.6 Å

PDB Description: Insights into the Ubiquitin Transfer Cascade from the refined structure of the activating enzyme for NEDD8
PDB Compounds: (C:) amyloid protein-binding protein 1

SCOPe Domain Sequences for d1yovc_:

Sequence; same for both SEQRES and ATOM records: (download)

>d1yovc_ c.111.1.2 (C:) Amyloid beta precursor protein-binding protein 1, APPBP1 {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1yovc_:

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Timeline for d1yovc_: