SCOPe 2.08: Domain d1yc5a1: 1yc5 A:1-245

Lineage for d1yc5a1 (1yc5 A:1-245)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

6. Protein NAD-dependent deacetylase NpdA [142126] (1 species)

7. Species Thermotoga maritima [TaxId:2336] [142127] (7 PDB entries)
   Uniprot Q9WYW0 1-245

8. Domain d1yc5a1: 1yc5 A:1-245 [122910]
   complexed with nca, zn

Details for d1yc5a1

PDB Entry: 1yc5, 1.4 Å

PDB Description: Sir2-p53 peptide-nicotinamide

PDB Compounds: (A:) NAD-dependent deacetylase

SCOPe Domain Sequences for d1yc5a1:

Sequence, based on SEQRES records:

>d1yc5a1 c.31.1.5 (A:1-245) NAD-dependent deacetylase NpdA {Thermotoga maritima [TaxId: 2336]}
mkmkefldllnesrltvtltgagistpsgipdfrgpngiykkysqnvfdidffyshpeef
yrfakegifpmlqakpnlahvllakleekglieavitqnidrlhqragskkvielhgnve
eyycvrcekkytvedvikklessdvplcddcnslirpnivffgenlpqdalreaiglssr
aslmivlgsslvvypaaelplitvrsggklvivnlgetpfddiatlkynmdvvefarrvm
eeggi

Sequence, based on observed residues (ATOM records):

>d1yc5a1 c.31.1.5 (A:1-245) NAD-dependent deacetylase NpdA {Thermotoga maritima [TaxId: 2336]}
mkmkefldllnesrltvtltgagistpsgipdfqnvfdidffyshpeefyrfakegifpm
lqakpnlahvllakleekglieavitqnidrlhqragskkvielhgnveeyycvrcekky
tvedvikklessdvplcddcnslirpnivffgenlpqdalreaiglssraslmivlgssl
vvypaaelplitvrsggklvivnlgetpfddiatlkynmdvvefarrvmeeggi

Timeline for d1yc5a1:

• d1yc5a1 first appeared in SCOP 1.73
  
• d1yc5a1 appears in SCOPe 2.07