SCOPe 2.05: Domain d1ya4b1: 1ya4 B:22-553

Lineage for d1ya4b1 (1ya4 B:22-553)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.69: alpha/beta-Hydrolases [53473] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

4. Superfamily c.69.1: alpha/beta-Hydrolases [53474] (42 families)
   many members have left-handed crossover connection between strand 8 and additional strand 9

5. Family c.69.1.1: Acetylcholinesterase-like [53475] (6 proteins)
   automatically mapped to Pfam PF00135

6. Protein Mammalian carboxylesterase (liver carboxylesterase I) [75282] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89768] (7 PDB entries)

8. Domain d1ya4b1: 1ya4 B:22-553 [122788]
   automatically matched to d1mx9d_
   complexed with ctx, nag, sia, so4

Details for d1ya4b1

PDB Entry: 1ya4, 3.2 Å

PDB Description: crystal structure of human liver carboxylesterase 1 in complex with tamoxifen

PDB Compounds: (B:) CES1 protein

SCOPe Domain Sequences for d1ya4b1:

Sequence; same for both SEQRES and ATOM records:

>d1ya4b1 c.69.1.1 (B:22-553) Mammalian carboxylesterase (liver carboxylesterase I) {Human (Homo sapiens) [TaxId: 9606]}
sppvvdtvhgkvlgkfvslegfaqpvaiflgipfakpplgplrftppqpaepwsfvknat
syppmctqdpkagqllselftnrkeniplklsedclylniytpadltkknrlpvmvwihg
gglmvgaastydglalaahenvvvvtiqyrlgiwgffstgdehsrgnwghldqvaalrwv
qdniasfggnpgsvtifgesaggesvsvlvlsplaknlfhraisesgvaltsvlvkkgdv
kplaeqiaitagcktttsavmvhclrqkteeellettlkmkflsldlqgdpresqpllgt
vidgmlllktpeelqaernfhtvpymvginkqefgwlipmlmsyplsegqldqktamsll
wksyplvciakelipeatekylggtddtvkkkdlfldliadvmfgvpsvivarnhrdaga
ptymyefqyrpsfssdmkpktvigdhgdelfsvfgapflkegaseeeirlskmvmkfwan
farngnpngeglphwpeynqkegylqigantqaaqklkdkevafwtnlfak

Timeline for d1ya4b1:

• d1ya4b1 first appeared in SCOP 1.73
  
• d1ya4b1 appears in SCOPe 2.04
  
• d1ya4b1 appears in SCOPe 2.06
  
• d1ya4b1 appears in the current release, SCOPe 2.08