SCOPe 2.01: Domain d1y5rb1: 1y5r B:25-289

Lineage for d1y5rb1 (1y5r B:25-289)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)

7. Species Mouse (Mus musculus) [TaxId:10090] [141879] (3 PDB entries)
   Uniprot P50172 24-298

8. Domain d1y5rb1: 1y5r B:25-289 [122652]
   automatically matched to 1Y5M A:25-289
   complexed with c0r, ndp

Details for d1y5rb1

PDB Entry: 1y5r, 3 Å

PDB Description: The crystal structure of murine 11b-hydroxysteroid dehydrogenase complexed with corticosterone

PDB Compounds: (B:) Corticosteroid 11-beta-dehydrogenase, isozyme 1

SCOPe Domain Sequences for d1y5rb1:

Sequence; same for both SEQRES and ATOM records:

>d1y5rb1 c.2.1.2 (B:25-289) 11-beta-hydroxysteroid dehydrogenase 1 {Mouse (Mus musculus) [TaxId: 10090]}
eefrpemlqgkkvivtgaskgigremayhlskmgahvvltarseeglqkvvsrclelgaa
sahyiagtmedmtfaeqfivkagklmggldmlilnhitqtslslfhddihsvrrvmevnf
lsyvvmstaalpmlkqsngsiavisslagkmtqpmiapysaskfaldgffstirtelyit
kvnvsitlcvlglidtetamkeisgiinaqaspkeecaleiikgtalrksevyydksplt
pillgnpgrkimeffslryynkdmf

Timeline for d1y5rb1:

• d1y5rb1 first appeared in SCOP 1.73
  
• d1y5rb1 appears in SCOP 1.75
  
• d1y5rb1 appears in SCOPe 2.02
  
• d1y5rb1 appears in the current release, SCOPe 2.08, called d1y5rb_