SCOPe 2.05: Domain d1y2cb_: 1y2c B:

Lineage for d1y2cb_ (1y2c B:)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein Catalytic domain of cyclic nucleotide phosphodiesterase pde4d [89151] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89152] (35 PDB entries)
   Uniprot Q08499 388-713

8. Domain d1y2cb_: 1y2c B: [122559]
   automated match to d1oyna_
   complexed with 3de, edo, mg, zn

Details for d1y2cb_

PDB Entry: 1y2c, 1.67 Å

PDB Description: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 3,5-dimethyl-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester

PDB Compounds: (B:) cAMP-specific 3',5'-cyclic phosphodiesterase 4D

SCOPe Domain Sequences for d1y2cb_:

Sequence; same for both SEQRES and ATOM records:

>d1y2cb_ a.211.1.2 (B:) Catalytic domain of cyclic nucleotide phosphodiesterase pde4d {Human (Homo sapiens) [TaxId: 9606]}
teqedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllktfkipvdtlity
lmtledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaaifasaihdvdhp
gvsnqflintnselalmyndssvlenhhlavgfkllqeencdifqnltkkqrqslrkmvi
divlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmvhcadlsnptkp
lqlyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfidyivhplwetwa
dlvhpdaqdildtlednrewyqstip

Timeline for d1y2cb_:

• d1y2cb_ first appeared in SCOP 1.73, called d1y2cb1
  
• d1y2cb_ appears in SCOPe 2.04
  
• d1y2cb_ appears in SCOPe 2.06
  
• d1y2cb_ appears in the current release, SCOPe 2.08