SCOPe 2.07: Domain d1xr3a1: 1xr3 A:6-261

Lineage for d1xr3a1 (1xr3 A:6-261)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein beta-keto acyl carrier protein reductase [51788] (8 species)

7. Species Streptomyces coelicolor [TaxId:1902] [117408] (8 PDB entries)
   Uniprot P16544 #SP

8. Domain d1xr3a1: 1xr3 A:6-261 [122245]
   complexed with isz, nap

Details for d1xr3a1

PDB Entry: 1xr3, 2.71 Å

PDB Description: Actinorhodin Polyketide Ketoreductase with NADP and the Inhibitor Isoniazid bound

PDB Compounds: (A:) Actinorhodin Polyketide Ketoreductase

SCOPe Domain Sequences for d1xr3a1:

Sequence; same for both SEQRES and ATOM records:

>d1xr3a1 c.2.1.2 (A:6-261) beta-keto acyl carrier protein reductase {Streptomyces coelicolor [TaxId: 1902]}
sevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelreagveadgrtcdvr
svpeiealvaavverygpvdvlvnnagrpgggataeladelwldvvetnltgvfrvtkqv
lkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalglelartgitvnav
cpgfvetpmaasvrehysdiwevsteeafdritarvpigryvqpsevaemvayligpgaa
avtaqalnvcgglgny

Timeline for d1xr3a1:

• d1xr3a1 first appeared in SCOP 1.73
  
• d1xr3a1 appears in SCOPe 2.06
  
• d1xr3a1 appears in the current release, SCOPe 2.08