SCOPe 2.06: Domain d1xjba2: 1xjb A:2-323

Lineage for d1xjba2 (1xjb A:2-323)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein 3-alpha-hydroxysteroid dehydrogenase [51439] (2 species)

7. Species Human (Homo sapiens), type III [TaxId:9606] [69383] (15 PDB entries)
   bile acid binding protein

8. Domain d1xjba2: 1xjb A:2-323 [122032]
   Other proteins in same PDB: d1xjba3
   automated match to d1j96a_
   complexed with act, bme, cit, edo, nap, so4

Details for d1xjba2

PDB Entry: 1xjb, 1.9 Å

PDB Description: crystal structure of human type 3 3alpha-hydroxysteroid dehydrogenase in complex with nadp(h), citrate and acetate molecules

PDB Compounds: (A:) Aldo-keto reductase family 1 member C2

SCOPe Domain Sequences for d1xjba2:

Sequence; same for both SEQRES and ATOM records:

>d1xjba2 c.1.7.1 (A:2-323) 3-alpha-hydroxysteroid dehydrogenase {Human (Homo sapiens), type III [TaxId: 9606]}
dskyqcvklndghfmpvlgfgtyapaevpkskaleavklaieagfhhidsahvynneeqv
glairskiadgsvkredifytsklwsnshrpelvrpalerslknlqldyvdlylihfpvs
vkpgeevipkdengkilfdtvdlcatweamekckdaglaksigvsnfnhrllemilnkpg
lkykpvcnqvechpyfnqrklldfckskdivlvaysalgshreepwvdpnspvlledpvl
calakkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltseemkaidglnr
nvryltldifagppnypfsdey

Timeline for d1xjba2:

• d1xjba2 first appeared in SCOP 1.73, called d1xjba1
  
• d1xjba2 was called d1xjba_ in SCOPe 2.05
  
• d1xjba2 appears in SCOPe 2.07
  
• d1xjba2 appears in the current release, SCOPe 2.08