SCOPe 2.08: Domain d1wxwa2: 1wxw A:65-382

Lineage for d1wxwa2 (1wxw A:65-382)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (61 families)

5. Family c.66.1.51: hypothetical RNA methyltransferase [142635] (4 proteins)
   C-terminal part of Pfam PF03602; similar to (Uracil-5-)-methyltransferase (Pfam PF05958)

6. Protein Hypothetical protein TTHA1280, middle and C-terminal domains [142638] (1 species)

7. Species Thermus thermophilus [TaxId:274] [142639] (3 PDB entries)
   Uniprot Q5SIT4 65-382

8. Domain d1wxwa2: 1wxw A:65-382 [121411]
   Other proteins in same PDB: d1wxwa1, d1wxwb1, d1wxwc1, d1wxwd1
   complexed with hez

Details for d1wxwa2

PDB Entry: 1wxw, 2.55 Å

PDB Description: Crystal structure of Tt1595, a putative SAM-dependent methyltransferase from Thermus thermophillus HB8

PDB Compounds: (A:) hypothetical protein TTHA1280

SCOPe Domain Sequences for d1wxwa2:

Sequence, based on SEQRES records:

>d1wxwa2 c.66.1.51 (A:65-382) Hypothetical protein TTHA1280, middle and C-terminal domains {Thermus thermophilus [TaxId: 274]}
aedpvaallenlaqalarreavlrqdpeggyrlvhaegdllpglvvdyyaghavvqatah
awegllpqvaealrphvqsvlakndartreleglplyvrpllgevpervqvqegrvrylv
dlragqktgayldqrenrlymerfrgeraldvfsyaggfalhlalgfrevvavdssaeal
rraeenarlnglgnvrvleanafdllrrlekegerfdlvvldppafakgkkdverayray
kevnlraikllkeggilatascshhmteplfyamvaeaaqdahrllrvvekrgqpfdhpv
llnhpethylkfavfqvl

Sequence, based on observed residues (ATOM records):

>d1wxwa2 c.66.1.51 (A:65-382) Hypothetical protein TTHA1280, middle and C-terminal domains {Thermus thermophilus [TaxId: 274]}
aedpvaallenlaqalarreavlrqdpeggyrlvhaegdllpglvvdyyaghavvqatah
awegllpqvaealrphvqsvlakndartreleglplyvrpllgevpervqvqegrvrylv
dlraayldqrenrlymerfrgeraldvfsyaggfalhlalgfrevvavdssaealrraee
narlnglgnvrvleanafdllrrlekegerfdlvvldppafakgkkdverayraykevnl
raikllkeggilatascshhmteplfyamvaeaaqdahrllrvvekrgqpfdhpvllnhp
ethylkfavfqvl

Timeline for d1wxwa2:

• d1wxwa2 first appeared in SCOP 1.73
  
• d1wxwa2 appears in SCOPe 2.07