SCOP 1.75: Domain d1wu1a1: 1wu1 A:16-243

Lineage for d1wu1a1 (1wu1 A:16-243)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (47 proteins)

6. Protein Coagulation factor Xa, protease domain [50574] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50575] (75 PDB entries)
   Uniprot P00742 235-467

8. Domain d1wu1a1: 1wu1 A:16-243 [121270]
   Other proteins in same PDB: d1wu1b1
   automatically matched to d1c5md_
   complexed with ca, d91

Details for d1wu1a1

PDB Entry: 1wu1, 2.3 Å

PDB Description: Factor Xa in complex with the inhibitor 4-[(5-chloroindol-2-yl)sulfonyl]-2-(2-methylpropyl)-1-[[5-(pyridin-4-yl) pyrimidin-2-yl]carbonyl]piperazine

PDB Compounds: (A:) coagulation factor x, heavy chain

SCOP Domain Sequences for d1wu1a1:

Sequence; same for both SEQRES and ATOM records:

>d1wu1a1 b.47.1.2 (A:16-243) Coagulation factor Xa, protease domain {Human (Homo sapiens) [TaxId: 9606]}
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmk

Timeline for d1wu1a1:

• d1wu1a1 first appeared in SCOP 1.73
  
• d1wu1a1 is called d1wu1a_ in SCOPe 2.01
  
• d1wu1a1 appears in the current release, SCOPe 2.08, called d1wu1a_