Lineage for d1wcib1 (1wci B:2-204)

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 828800Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 828801Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 828995Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (4 proteins)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
  6. 829003Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module [88742] (2 species)
  7. 829004Species Human (Homo sapiens) [TaxId:9606] [88743] (21 PDB entries)
    Uniprot P21953 52-392
  8. 829014Domain d1wcib1: 1wci B:2-204 [120891]
    Other proteins in same PDB: d1wcia1, d1wcib2
    automatically matched to d1olsb1
    complexed with cl, gol, k, mn, wwf

Details for d1wcib1

PDB Entry: 1wci (more details), 1.84 Å

PDB Description: reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
PDB Compounds: (B:) 2-oxoisovalerate dehydrogenase beta subunit

SCOP Domain Sequences for d1wcib1:

Sequence, based on SEQRES records: (download)

>d1wcib1 c.36.1.7 (B:2-204) Branched-chain alpha-keto acid dehydrogenase, Pyr module {Human (Homo sapiens) [TaxId: 9606]}
ahftfqpdpepreygqtqkmnlfqsvtsaldnslakdptavifgedvafggvfrctvglr
dkygkdrvfntplceqgivgfgigiavtgataiaeiqfadyifpafdqivneaakyryrs
gdlfncgsltirspwgcvghgalyhsqspeaffahcpgikvviprspfqakglllscied
knpciffepkilyraaaeevpie

Sequence, based on observed residues (ATOM records): (download)

>d1wcib1 c.36.1.7 (B:2-204) Branched-chain alpha-keto acid dehydrogenase, Pyr module {Human (Homo sapiens) [TaxId: 9606]}
ahftfqeygqtqkmnlfqsvtsaldnslakdptavifgedvafggvfrctvglrdkygkd
rvfntplceqgivgfgigiavtgataiaeiqfadyifpafdqivneaakyryrsgdlfnc
gsltirspwgcvghgalyhsqspeaffahcpgikvviprspfqakglllsciedknpcif
fepkilyraaaeevpie

SCOP Domain Coordinates for d1wcib1:

Click to download the PDB-style file with coordinates for d1wcib1.
(The format of our PDB-style files is described here.)

Timeline for d1wcib1:

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Domains from same chain:
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d1wcib2
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Domains from other chains:
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d1wcia1