SCOPe 2.08: Domain d1wcia_: 1wci A:

Lineage for d1wcia_ (1wci A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5 proteins)
   parent family to TK and PFOR
   heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

6. Protein automated matches [190098] (3 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [186820] (5 PDB entries)

8. Domain d1wcia_: 1wci A: [120890]
   Other proteins in same PDB: d1wcib1, d1wcib2
   automated match to d1olxa_
   complexed with cl, gol, k, mn, wwf

Details for d1wcia_

PDB Entry: 1wci, 1.84 Å

PDB Description: reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch

PDB Compounds: (A:) 2-oxoisovalerate dehydrogenase alpha subunit

SCOPe Domain Sequences for d1wcia_:

Sequence, based on SEQRES records:

>d1wcia_ c.36.1.11 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kpqfpgasaefidklefiqpnvisgipiyrvmdrqgqiinpsedphlpkekvlklyksmt
llntmdrilyesqrqgrisfymtnygeegthvgsaaaldntdlvfgqyreagvlmyrdyp
lelfmaqcygnisdlgkgrqmpvhygckerhfvtissplatqipqavgaayaakrananr
vvicyfgegaasegdahagfnfaatlecpiiffcrnngyaistptseqyrgdgiaargpg
ygimsirvdgndvfavynatkearrravaenqpflieamtyrighhstsddssayrsvde
vnywdkqdhpisrlrhyllsqgwwdeeqekawrkqsrrkvmeafeqaerkpkpnpnllfs
dvyqempaqlrkqqeslarhlqtygehypldhfdk

Sequence, based on observed residues (ATOM records):

>d1wcia_ c.36.1.11 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kpqfpgasaefidklefiqpnvisgipiyrvmdrqgqiinpsedphlpkekvlklyksmt
llntmdrilyesqrqgrisfymtnygeegthvgsaaaldntdlvfgqyreagvlmyrdyp
lelfmaqcygnisdlgkgrqmpvhygckerhfvtissplatqipqavgaayaakrananr
vvicyfgegaasegdahagfnfaatlecpiiffcrnngyaistptseqyrgdgiaargpg
ygimsirvdgndvfavynatkearrravaenqpflieamtyrighhstsddssayrwdkq
dhpisrlrhyllsqgwwdeeqekawrkqsrrkvmeafeqaerkpkpnpnllfsdvyqemp
aqlrkqqeslarhlqtygehypldhfdk

Timeline for d1wcia_:

• d1wcia_ first appeared in SCOP 1.73, called d1wcia1
  
• d1wcia_ appears in SCOPe 2.07