SCOPe 2.01: Domain d1vyqa1: 1vyq A:1-159

Lineage for d1vyqa1 (1vyq A:1-159)

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.85: beta-clip [51268] (7 superfamilies)
   double-stranded ribbon sharply bent in two places; the ribbon ends form incomplete barrel; jelly-roll

4. Superfamily b.85.4: dUTPase-like [51283] (2 families)
   forms tight trimer through an additional beta-sheet in each subunit
   subunit beta-sheets are orthogonally packed around the three-fold axis

5. Family b.85.4.1: dUTPase-like [51284] (5 proteins)

6. Protein Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) [51285] (7 species)

7. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [141654] (1 PDB entry)
   Uniprot Q8II92 1-159

8. Domain d1vyqa1: 1vyq A:1-159 [120548]
   Other proteins in same PDB: d1vyqb_, d1vyqc_
   complexed with dux

Details for d1vyqa1

PDB Entry: 1vyq, 2.4 Å

PDB Description: novel inhibitors of plasmodium falciparum dutpase provide a platform for anti-malarial drug design

PDB Compounds: (A:) deoxyuridine 5'-triphosphate nucleotidohydrolase

SCOPe Domain Sequences for d1vyqa1:

Sequence, based on SEQRES records:

>d1vyqa1 b.85.4.1 (A:1-159) Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
mhlkivclsdevremyknhkthhegdsgldlfivkdevlkpksttfvklgikaialqyks
nyyykceksenkkkdddksnivntsfllfprssisktplrlansiglidagyrgeiiaal
dntsdqeyhikkndklvqlvsftgeplsfelveeldets

Sequence, based on observed residues (ATOM records):

>d1vyqa1 b.85.4.1 (A:1-159) Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
mhlkivclsdevremyknhkthhedsgldlfivkdevlkpksttfvklgikaialqyksn
yynivntsfllfprssisktplrlansiglidagyrgeiiaaldntsdqeyhikkndklv
qlvsftgeplsfelveeldets

Timeline for d1vyqa1:

• d1vyqa1 first appeared in SCOP 1.73
  
• d1vyqa1 appears in SCOP 1.75
  
• d1vyqa1 appears in SCOPe 2.02
  
• d1vyqa1 appears in the current release, SCOPe 2.08