Lineage for d1u72a1 (1u72 A:1-186)

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 843142Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 843143Superfamily c.71.1: Dihydrofolate reductase-like [53597] (2 families) (S)
  5. 843144Family c.71.1.1: Dihydrofolate reductases [53598] (3 proteins)
  6. 843259Protein Dihydrofolate reductases, eukaryotic type [53605] (4 species)
  7. 843284Species Human (Homo sapiens) [TaxId:9606] [53607] (25 PDB entries)
  8. 843299Domain d1u72a1: 1u72 A:1-186 [119614]
    automatically matched to d1drf__
    complexed with mtx, ndp

Details for d1u72a1

PDB Entry: 1u72 (more details), 1.9 Å

PDB Description: Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrfolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH
PDB Compounds: (A:) dihydrofolate reductase

SCOP Domain Sequences for d1u72a1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1u72a1 c.71.1.1 (A:1-186) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

SCOP Domain Coordinates for d1u72a1:

Click to download the PDB-style file with coordinates for d1u72a1.
(The format of our PDB-style files is described here.)

Timeline for d1u72a1: