SCOPe 2.06: Domain d1u5ia3: 1u5i A:2-355

Lineage for d1u5ia3 (1u5i A:2-355)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (24 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.3: Calpain large subunit, catalytic domain (domain II) [54040] (1 protein)
   automatically mapped to Pfam PF00648

6. Protein Calpain large subunit, catalytic domain (domain II) [54041] (6 species)
   includes the N-terminal 'sequence' domain I

7. Species Norway rat (Rattus norvegicus), M-type [TaxId:10116] [54043] (3 PDB entries)

8. Domain d1u5ia3: 1u5i A:2-355 [119549]
   Other proteins in same PDB: d1u5ia1, d1u5ia2, d1u5ib_
   automatically matched to d1df0a3
   mutant

Details for d1u5ia3

PDB Entry: 1u5i, 2.86 Å

PDB Description: crystal structure analysis of rat m-calpain mutant lys10 thr

PDB Compounds: (A:) Calpain 2, large [catalytic] subunit precursor

SCOPe Domain Sequences for d1u5ia3:

Sequence, based on SEQRES records:

>d1u5ia3 d.3.1.3 (A:2-355) Calpain large subunit, catalytic domain (domain II) {Norway rat (Rattus norvegicus), M-type [TaxId: 10116]}
agiamklatdreaaeglgsheraikylnqdyetlrnecleagalfqdpsfpalpsslgfk
elgpyssktrgiewkrpteicadpqfiiggatrtdicqgalgdswllaaiasltlneeil
arvvpldqsfqenyagifhfqfwqygewvevvvddrlptkdgellfvhsaegsefwsall
ekayakingcyealsggattegfedftggiaewyelrkpppnlfkiiqkalekgsllgcs
iditsaadseavtyqklvkghaysvtgaeevessgslqklirirnpwgqvewtgkwndnc
pswntvdpevranlterqedgefwmsfsdflrhysrleicnltpdtltcdsykk

Sequence, based on observed residues (ATOM records):

>d1u5ia3 d.3.1.3 (A:2-355) Calpain large subunit, catalytic domain (domain II) {Norway rat (Rattus norvegicus), M-type [TaxId: 10116]}
agiamklatdreaaeglgsheraikylnqdyetlrnecleagalfqdpsfpalpsslgfk
elgpyssktrgiewkrpteicadpqfiiggatrtdicqgalgdswllaaiasltlneeil
arvvpldqsfqenyagifhfqfwqygewvevvvddrlptkdgellfvhsaegsefwsall
ekayakingcyealsggattegfedftggiaewyelrkpppnlfkiiqkalekgsllgcs
idighaysvtgaeevqklirirnpwgqgefwmsfsdflrhysrleicnltpdtltcdsyk
k

Timeline for d1u5ia3:

• d1u5ia3 first appeared in SCOP 1.73
  
• d1u5ia3 appears in SCOPe 2.05
  
• d1u5ia3 appears in SCOPe 2.07
  
• d1u5ia3 appears in the current release, SCOPe 2.08