SCOP 1.73: Domain d1tv5a1: 1tv5 A:158-566

Lineage for d1tv5a1 (1tv5 A:158-566)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.4: FMN-linked oxidoreductases [51395] (1 family)

5. Family c.1.4.1: FMN-linked oxidoreductases [51396] (18 proteins)

6. Protein Dihydroorotate dehydrogenase [51397] (7 species)

7. Species Plasmodium falciparum [TaxId:5833] [141759] (1 PDB entry)
   homolog, mitochonrial

8. Domain d1tv5a1: 1tv5 A:158-566 [119347]
   complexed with a26, fmn, n8e, oro, so4; mutant

Details for d1tv5a1

PDB Entry: 1tv5, 2.4 Å

PDB Description: Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor

PDB Compounds: (A:) Dihydroorotate dehydrogenase homolog, mitochondrial

SCOP Domain Sequences for d1tv5a1:

Sequence, based on SEQRES records:

>d1tv5a1 c.1.4.1 (A:158-566) Dihydroorotate dehydrogenase {Plasmodium falciparum [TaxId: 5833]}
fesynpefflydiflkfclkyidgeichdlflllgkynilpydtsndsiyactnikhldf
inpfgvaagfdkngvcidsilklgfsfieigtitprgqtgnakprifrdvesrsiinscg
fnnmgcdkvtenlilfrkrqeedkllskhivgvsigknkdtvnivddlkycinkigryad
yiainvsspntpglrdnqeagklkniilsvkeeidnleknnimndestynednkivekkn
nfnknnshmmkdakdnflwfnttkkkplvfvklapdlnqeqkkeiadvlletnidgmiis
ntttqindiksfenkkggvsgaklkdistkficemynytnkqipiiasggifsgldalek
ieagasvcqlysclvfngmksavqikrelnhllyqrgyynlkeaigrkh

Sequence, based on observed residues (ATOM records):

>d1tv5a1 c.1.4.1 (A:158-566) Dihydroorotate dehydrogenase {Plasmodium falciparum [TaxId: 5833]}
fesynpefflydiflkfclkyidgeichdlflllgkynilpydtsndsiyactnikhldf
inpfgvaagfdkngvcidsilklgfsfieigtitprgqtgnakprifrdvesrsiinscg
fnnmgcdkvtenlilfrkrqeedkllskhivgvsigknkdtvnivddlkycinkigryad
yiainvsspntpglrdnqeagklkniilsvkeeidnleflwfnttkkkplvfvklapdln
qeqkkeiadvlletnidgmiisntttqindiksfenkkggvsgaklkdistkficemyny
tnkqipiiasggifsgldalekieagasvcqlysclvfngmksavqikrelnhllyqrgy
ynlkeaigrkh

Timeline for d1tv5a1:

• d1tv5a1 is new in SCOP 1.73
  
• d1tv5a1 appears in SCOP 1.75
  
• d1tv5a1 appears in the current release, SCOPe 2.08