SCOPe 2.02: Domain d1t8ia3: 1t8i A:201-430

Lineage for d1t8ia3 (1t8i A:201-430)

1. Root: SCOPe 2.02

2. Class e: Multi-domain proteins (alpha and beta) [56572] (66 folds)

3. Fold e.15: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56740] (1 superfamily)
   2 domains: alpha+beta and all-beta

4. Superfamily e.15.1: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56741] (1 family)

5. Family e.15.1.1: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56742] (1 protein)

6. Protein Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56743] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56744] (15 PDB entries)
   Uniprot P11387 203-765 ! Uniprot P11387 203-767

8. Domain d1t8ia3: 1t8i A:201-430 [119174]
   Other proteins in same PDB: d1t8ia1, d1t8ia2
   automatically matched to d1k4sa2
   protein/DNA complex; complexed with ehd

Details for d1t8ia3

PDB Entry: 1t8i, 3 Å

PDB Description: human dna topoisomerase i (70 kda) in complex with the poison camptothecin and covalent complex with a 22 base pair dna duplex

PDB Compounds: (A:) DNA topoisomerase I

SCOPe Domain Sequences for d1t8ia3:

Sequence; same for both SEQRES and ATOM records:

>d1t8ia3 e.15.1.1 (A:201-430) Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment {Human (Homo sapiens) [TaxId: 9606]}
qkwkwweeerypegikwkflehkgpvfappyeplpenvkfyydgkvmklspkaeevatff
akmldheyttkeifrknffkdwrkemtneekniitnlskcdftqmsqyfkaqtearkqms
keeklkikeenekllkeygfcimdnhkerianfkieppglfrgrgnhpkmgmlkrrimpe
diiincskdakvpspppghkwkevrhdnkvtwlvswteniqgsikyimln

Timeline for d1t8ia3:

• d1t8ia3 first appeared in SCOP 1.73
  
• d1t8ia3 appears in SCOPe 2.01
  
• d1t8ia3 appears in SCOPe 2.03
  
• d1t8ia3 appears in the current release, SCOPe 2.08