Lineage for d1t8ia2 (1t8i A:431-633,A:714-765)

  1. Root: SCOPe 2.06
  2. 2170735Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2233332Fold d.163: DNA breaking-rejoining enzymes [56348] (1 superfamily)
    core: alpha3-beta3-alpha4; one side of beta-sheet is exposed
  4. 2233333Superfamily d.163.1: DNA breaking-rejoining enzymes [56349] (2 families) (S)
  5. 2233435Family d.163.1.2: Eukaryotic DNA topoisomerase I, catalytic core [56361] (1 protein)
  6. 2233436Protein Eukaryotic DNA topoisomerase I, catalytic core [56362] (2 species)
  7. 2233437Species Human (Homo sapiens) [TaxId:9606] [56363] (15 PDB entries)
    Uniprot P11387 203-765 ! Uniprot P11387 203-767
  8. 2233448Domain d1t8ia2: 1t8i A:431-633,A:714-765 [119173]
    Other proteins in same PDB: d1t8ia1, d1t8ia3
    automatically matched to d1ej9a1
    protein/DNA complex; complexed with ehd

Details for d1t8ia2

PDB Entry: 1t8i (more details), 3 Å

PDB Description: human dna topoisomerase i (70 kda) in complex with the poison camptothecin and covalent complex with a 22 base pair dna duplex
PDB Compounds: (A:) DNA topoisomerase I

SCOPe Domain Sequences for d1t8ia2:

Sequence; same for both SEQRES and ATOM records: (download)

>d1t8ia2 d.163.1.2 (A:431-633,A:714-765) Eukaryotic DNA topoisomerase I, catalytic core {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1t8ia2:

Click to download the PDB-style file with coordinates for d1t8ia2.
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Timeline for d1t8ia2: