Lineage for d1t8ia1 (1t8i A:636-712)

  1. Root: SCOPe 2.08
  2. 2685877Class a: All alpha proteins [46456] (290 folds)
  3. 2689745Fold a.2: Long alpha-hairpin [46556] (20 superfamilies)
    2 helices; antiparallel hairpin, left-handed twist
  4. 2689995Superfamily a.2.8: Eukaryotic DNA topoisomerase I, dispensable insert domain [46596] (1 family) (S)
  5. 2689996Family a.2.8.1: Eukaryotic DNA topoisomerase I, dispensable insert domain [46597] (1 protein)
  6. 2689997Protein Eukaryotic DNA topoisomerase I, dispensable insert domain [46598] (1 species)
  7. 2689998Species Human (Homo sapiens) [TaxId:9606] [46599] (9 PDB entries)
    Uniprot P11387 203-767
  8. 2690005Domain d1t8ia1: 1t8i A:636-712 [119172]
    Other proteins in same PDB: d1t8ia2, d1t8ia3
    automatically matched to d1rrja1
    protein/DNA complex; complexed with ehd

Details for d1t8ia1

PDB Entry: 1t8i (more details), 3 Å

PDB Description: human dna topoisomerase i (70 kda) in complex with the poison camptothecin and covalent complex with a 22 base pair dna duplex
PDB Compounds: (A:) DNA topoisomerase I

SCOPe Domain Sequences for d1t8ia1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1t8ia1 a.2.8.1 (A:636-712) Eukaryotic DNA topoisomerase I, dispensable insert domain {Human (Homo sapiens) [TaxId: 9606]}
ppktfeksmmnlqtkidakkeqladarrdlksakadakvmkdaktkkvveskkkavqrle
eqlmklevqatdreenk

SCOPe Domain Coordinates for d1t8ia1:

Click to download the PDB-style file with coordinates for d1t8ia1.
(The format of our PDB-style files is described here.)

Timeline for d1t8ia1: