SCOPe 2.07: Domain d1skxa_: 1skx A:

Lineage for d1skxa_ (1skx A:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Pregnane x receptor, PXR [63624] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63625] (31 PDB entries)

8. Domain d1skxa_: 1skx A: [118970]
   automated match to d1m13a_
   complexed with rfp

Details for d1skxa_

PDB Entry: 1skx, 2.8 Å

PDB Description: Structural Disorder in the Complex of Human PXR and the Macrolide Antibiotic Rifampicin

PDB Compounds: (A:) orphan nuclear receptor pxr

SCOPe Domain Sequences for d1skxa_:

Sequence, based on SEQRES records:

>d1skxa_ a.123.1.1 (A:) Pregnane x receptor, PXR {Human (Homo sapiens) [TaxId: 9606]}
lteeqrmmirelmdaqmktfdttfshfknfrlpgvlssgcelpeslqapsreeaakwsqv
rkdlcslkvslqlrgedgsvwnykppadsggkeifsllphmadmstymfkgiisfakvis
yfrdlpiedqisllkgaafelcqlrfntvfnaetgtwecgrlsycledtaggfqqlllep
mlkfhymlkklqlheeeyvlmqaislfspdrpgvlqhrvvdqlqeqfaitlksyiecnrp
qpahrflflkimamltelrsinaqhtqrllriqdihpfatplmqelfgi

Sequence, based on observed residues (ATOM records):

>d1skxa_ a.123.1.1 (A:) Pregnane x receptor, PXR {Human (Homo sapiens) [TaxId: 9606]}
lteeqrmmirelmdaqmktfdttfshfknfrlpgvkvslqlrgedgsvwnykppifsllp
hmadmstymfkgiisfakvisyfrdlpiedqisllkgaafelcqlrfntvfnaetgtwec
grlsyclelllepmlkfhymlkklqlheeeyvlmqaislfspdrpgvlqhrvvdqlqeqf
aitlksyiecnrpqpahrflflkimamltelrsinaqhtqrllriqdihpfatplmqelf
gi

Timeline for d1skxa_:

• d1skxa_ first appeared in SCOP 1.73, called d1skxa1
  
• d1skxa_ appears in SCOPe 2.06
  
• d1skxa_ appears in the current release, SCOPe 2.08