SCOPe 2.08: Domain d1seua3: 1seu A:201-430

Lineage for d1seua3 (1seu A:201-430)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.15: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56740] (1 superfamily)
   2 domains: alpha+beta and all-beta

4. Superfamily e.15.1: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56741] (1 family)
   automatically mapped to Pfam PF02919

5. Family e.15.1.1: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56742] (1 protein)

6. Protein Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56743] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56744] (15 PDB entries)
   Uniprot P11387 203-765 ! Uniprot P11387 203-767

8. Domain d1seua3: 1seu A:201-430 [118954]
   Other proteins in same PDB: d1seua1, d1seua2
   automatically matched to d1k4sa2
   protein/DNA complex; complexed with sa3

Details for d1seua3

PDB Entry: 1seu, 3 Å

PDB Description: human dna topoisomerase i (70 kda) in complex with the indolocarbazole sa315f and covalent complex with a 22 base pair dna duplex

PDB Compounds: (A:) DNA topoisomerase I

SCOPe Domain Sequences for d1seua3:

Sequence; same for both SEQRES and ATOM records:

>d1seua3 e.15.1.1 (A:201-430) Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment {Human (Homo sapiens) [TaxId: 9606]}
qkwkwweeerypegikwkflehkgpvfappyeplpenvkfyydgkvmklspkaeevatff
akmldheyttkeifrknffkdwrkemtneekniitnlskcdftqmsqyfkaqtearkqms
keeklkikeenekllkeygfcimdnhkerianfkieppglfrgrgnhpkmgmlkrrimpe
diiincskdakvpspppghkwkevrhdnkvtwlvswteniqgsikyimln

Timeline for d1seua3:

• d1seua3 first appeared in SCOP 1.73
  
• d1seua3 appears in SCOPe 2.07