Lineage for Protein: Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2108258Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 2108259Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 2108430Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (5 protein domains)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
    automatically mapped to Pfam PF02779
  6. 2108496Protein Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain [117522] (1 species)

Species:

More info for Protein Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module

Timeline for Protein Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module:

  • Protein Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module first appeared in SCOP 1.71
  • Protein Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module appears in SCOPe 2.05