Lineage for Species: Leishmania mexicana mexicana [TaxId: 44270]
- Root: SCOPe 2.05
Class c: Alpha and beta proteins (a/b) [51349] (148 folds) 
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) 
there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
Family c.36.1.6: TK-like Pyr module [88735] (2 proteins)
different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
Protein Transketolase (TK), Pyr module [88736] (4 species) 
Species Leishmania mexicana mexicana [TaxId:44270] [117521] (1 PDB entry)
Uniprot Q8MPM3
PDB entry in Species: Leishmania mexicana mexicana [TaxId: 44270]:
- Domain(s) for 1r9j:
Domain d1r9ja1: 1r9j A:337-526 [111722]
Other proteins in same PDB: d1r9ja2, d1r9ja3, d1r9jb2, d1r9jb3
complexed with ca, tpp
Domain d1r9jb1: 1r9j B:337-526 [111725]
Other proteins in same PDB: d1r9ja2, d1r9ja3, d1r9jb2, d1r9jb3
complexed with ca, tpp
More info for Species Leishmania mexicana mexicana [TaxId:44270] from c.36.1.6 Transketolase (TK), Pyr module
Timeline for Species Leishmania mexicana mexicana [TaxId:44270] from c.36.1.6 Transketolase (TK), Pyr module:
- Species Leishmania mexicana mexicana [TaxId:44270] from c.36.1.6 Transketolase (TK), Pyr module first appeared in SCOP 1.71
- Species Leishmania mexicana mexicana [TaxId:44270] from c.36.1.6 Transketolase (TK), Pyr module appears in SCOPe 2.04
- Species Leishmania mexicana mexicana [TaxId:44270] from c.36.1.6 Transketolase (TK), Pyr module appears in SCOPe 2.06
- Species Leishmania mexicana mexicana [TaxId:44270] from c.36.1.6 Transketolase (TK), Pyr module appears in the current release, SCOPe 2.08