SCOPe 2.06: Species: Human (Homo sapiens) [TaxId: 9606]

Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

Root: SCOPe 2.06
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
Species Human (Homo sapiens) [TaxId:9606] [117424] (29 PDB entries)
Uniprot P28845

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

Domain(s) for 1xu7:
1. Domain d1xu7a1: 1xu7 A:24-283 [116048]
  Other proteins in same PDB: d1xu7a2, d1xu7b2, d1xu7c2, d1xu7d2
  complexed with cps, ndp
2. Domain d1xu7b1: 1xu7 B:24-282 [116049]
  Other proteins in same PDB: d1xu7a2, d1xu7b2, d1xu7c2, d1xu7d2
  complexed with cps, ndp
3. Domain d1xu7c1: 1xu7 C:24-282 [116050]
  Other proteins in same PDB: d1xu7a2, d1xu7b2, d1xu7c2, d1xu7d2
  complexed with cps, ndp
4. Domain d1xu7d1: 1xu7 D:24-281 [116051]
  Other proteins in same PDB: d1xu7a2, d1xu7b2, d1xu7c2, d1xu7d2
  complexed with cps, ndp
Domain(s) for 1xu9:
1. Domain d1xu9a1: 1xu9 A:24-289 [116052]
  Other proteins in same PDB: d1xu9a2, d1xu9b2, d1xu9c2, d1xu9d2
  complexed with cps, mes, ndp
2. Domain d1xu9b1: 1xu9 B:24-289 [116053]
  Other proteins in same PDB: d1xu9a2, d1xu9b2, d1xu9c2, d1xu9d2
  complexed with cps, mes, ndp
3. Domain d1xu9c1: 1xu9 C:24-281 [116054]
  Other proteins in same PDB: d1xu9a2, d1xu9b2, d1xu9c2, d1xu9d2
  complexed with cps, mes, ndp
4. Domain d1xu9d1: 1xu9 D:24-281 [116055]
  Other proteins in same PDB: d1xu9a2, d1xu9b2, d1xu9c2, d1xu9d2
  complexed with cps, mes, ndp
Domain(s) for 2bel:
1. Domain d2bela_: 2bel A: [116694]
  Other proteins in same PDB: d2belc2, d2beld2
  complexed with cbo, cl, nap
2. Domain d2belb_: 2bel B: [116695]
  Other proteins in same PDB: d2belc2, d2beld2
  complexed with cbo, cl, nap
3. Domain d2belc1: 2bel C:26-271 [116696]
  Other proteins in same PDB: d2belc2, d2beld2
  complexed with cbo, cl, nap
4. Domain d2beld1: 2bel D:26-277 [116697]
  Other proteins in same PDB: d2belc2, d2beld2
  complexed with cbo, cl, nap
Domain(s) for 2ilt:
- Domain d2ilta1: 2ilt A:24-285 [165610]
  Other proteins in same PDB: d2ilta2
  automated match to d1xu9a_
  complexed with nap, ni, nn1
Domain(s) for 2irw:
1. Domain d2irwa_: 2irw A: [137593]
  automated match to d2irwa1
  complexed with nap, nn4
2. Domain d2irwb_: 2irw B: [137594]
  automated match to d2irwb1
  complexed with nap, nn4
3. Domain d2irwc_: 2irw C: [137595]
  automated match to d2irwd1
  complexed with nap, nn4
4. Domain d2irwd_: 2irw D: [137596]
  automated match to d2irwd1
  complexed with nap, nn4
5. Domain d2irwe_: 2irw E: [137597]
  automated match to d2irwd1
  complexed with nap, nn4
6. Domain d2irwf_: 2irw F: [137598]
  automated match to d2irwf1
  complexed with nap, nn4
7. Domain d2irwg_: 2irw G: [137599]
  automated match to d2irwg1
  complexed with nap, nn4
8. Domain d2irwh_: 2irw H: [137600]
  automated match to d2irwg1
  complexed with nap, nn4
Domain(s) for 2rbe:
1. Domain d2rbea_: 2rbe A: [151846]
  automated match to d1xu9a_
  complexed with ndp, zmg
2. Domain d2rbeb_: 2rbe B: [151847]
  automated match to d1xu9a_
  complexed with ndp, zmg
3. Domain d2rbec_: 2rbe C: [151848]
  automated match to d1xu9a_
  complexed with ndp, zmg
4. Domain d2rbed_: 2rbe D: [151849]
  automated match to d1xu9a_
  complexed with ndp, zmg
Domain(s) for 3byz:
1. Domain d3byza_: 3byz A: [155734]
  automated match to d1xu9a_
  complexed with h11, ndp
2. Domain d3byzb_: 3byz B: [155735]
  automated match to d1xu9a_
  complexed with h11, ndp
3. Domain d3byzc_: 3byz C: [155736]
  automated match to d1xu9a_
  complexed with h11, ndp
4. Domain d3byzd_: 3byz D: [155737]
  automated match to d1xu9a_
  complexed with h11, ndp
Domain(s) for 3bzu:
1. Domain d3bzua_: 3bzu A: [155788]
  Other proteins in same PDB: d3bzub3
  automated match to d1xu9a_
  complexed with a21, nap
2. Domain d3bzub2: 3bzu B:24-283 [155789]
  Other proteins in same PDB: d3bzub3
  automated match to d1xu9a_
  complexed with a21, nap
3. Domain d3bzuc_: 3bzu C: [155790]
  Other proteins in same PDB: d3bzub3
  automated match to d1xu9a_
  complexed with a21, nap
4. Domain d3bzud_: 3bzu D: [155791]
  Other proteins in same PDB: d3bzub3
  automated match to d1xu9a_
  complexed with a21, nap
Domain(s) for 3ch6:
1. Domain d3ch6a_: 3ch6 A: [173241]
  Other proteins in same PDB: d3ch6b2, d3ch6d2
  automated match to d1xu9a_
  complexed with 311, nap; mutant
2. Domain d3ch6b1: 3ch6 B:24-288 [173242]
  Other proteins in same PDB: d3ch6b2, d3ch6d2
  automated match to d1xu9a_
  complexed with 311, nap; mutant
3. Domain d3ch6d1: 3ch6 D:24-284 [173243]
  Other proteins in same PDB: d3ch6b2, d3ch6d2
  automated match to d1xu9a_
  complexed with 311, nap; mutant
4. Domain d3ch6e_: 3ch6 E: [173244]
  Other proteins in same PDB: d3ch6b2, d3ch6d2
  automated match to d1xu9a_
  complexed with 311, nap; mutant
Domain(s) for 3czr:
1. Domain d3czra2: 3czr A:24-285 [157154]
  Other proteins in same PDB: d3czra3, d3czrb3
  automated match to d1xu9a_
  complexed with 3cz, cps, nap
2. Domain d3czrb2: 3czr B:24-283 [157155]
  Other proteins in same PDB: d3czra3, d3czrb3
  automated match to d1xu9a_
  complexed with 3cz, cps, nap
Domain(s) for 3d3e:
1. Domain d3d3ea2: 3d3e A:24-284 [157280]
  Other proteins in same PDB: d3d3ea3, d3d3eb3, d3d3ec3, d3d3ed3
  automated match to d1xu9a_
  complexed with d3e, nap
2. Domain d3d3eb2: 3d3e B:24-281 [157281]
  Other proteins in same PDB: d3d3ea3, d3d3eb3, d3d3ec3, d3d3ed3
  automated match to d1xu9a_
  complexed with d3e, nap
3. Domain d3d3ec2: 3d3e C:24-281 [157282]
  Other proteins in same PDB: d3d3ea3, d3d3eb3, d3d3ec3, d3d3ed3
  automated match to d1xu9a_
  complexed with d3e, nap
4. Domain d3d3ed2: 3d3e D:24-281 [157283]
  Other proteins in same PDB: d3d3ea3, d3d3eb3, d3d3ec3, d3d3ed3
  automated match to d1xu9a_
  complexed with d3e, nap
Domain(s) for 3d4n:
1. Domain d3d4na2: 3d4n A:24-282 [157296]
  Other proteins in same PDB: d3d4na3, d3d4nb3, d3d4nc3, d3d4nd3
  automated match to d1xu9a_
  complexed with d4n, nap
2. Domain d3d4nb2: 3d4n B:24-284 [157297]
  Other proteins in same PDB: d3d4na3, d3d4nb3, d3d4nc3, d3d4nd3
  automated match to d1xu9a_
  complexed with d4n, nap
3. Domain d3d4nc2: 3d4n C:24-281 [157298]
  Other proteins in same PDB: d3d4na3, d3d4nb3, d3d4nc3, d3d4nd3
  automated match to d1xu9a_
  complexed with d4n, nap
4. Domain d3d4nd2: 3d4n D:24-281 [157299]
  Other proteins in same PDB: d3d4na3, d3d4nb3, d3d4nc3, d3d4nd3
  automated match to d1xu9a_
  complexed with d4n, nap
Domain(s) for 3d5q:
1. Domain d3d5qa2: 3d5q A:24-289 [157399]
  Other proteins in same PDB: d3d5qa3, d3d5qb3, d3d5qc3, d3d5qd3
  automated match to d1xu9a_
  complexed with nap, t30
2. Domain d3d5qb2: 3d5q B:24-284 [157400]
  Other proteins in same PDB: d3d5qa3, d3d5qb3, d3d5qc3, d3d5qd3
  automated match to d1xu9a_
  complexed with nap, t30
3. Domain d3d5qc2: 3d5q C:24-281 [157401]
  Other proteins in same PDB: d3d5qa3, d3d5qb3, d3d5qc3, d3d5qd3
  automated match to d1xu9a_
  complexed with nap, t30
4. Domain d3d5qd2: 3d5q D:24-281 [157402]
  Other proteins in same PDB: d3d5qa3, d3d5qb3, d3d5qc3, d3d5qd3
  automated match to d1xu9a_
  complexed with nap, t30
Domain(s) for 3ey4:
1. Domain d3ey4a_: 3ey4 A: [245988]
  automated match to d3pdjb_
  complexed with 352, ndp
2. Domain d3ey4b_: 3ey4 B: [245989]
  automated match to d3pdjb_
  complexed with 352, ndp
3. Domain d3ey4c_: 3ey4 C: [245990]
  automated match to d3pdjb_
  complexed with 352, ndp
4. Domain d3ey4d_: 3ey4 D: [245991]
  automated match to d3pdjb_
  complexed with 352, ndp
Domain(s) for 3fco:
1. Domain d3fcoa1: 3fco A:24-289 [175688]
  Other proteins in same PDB: d3fcoa2, d3fcob2
  automated match to d1xu9a_
  complexed with iig, nap
2. Domain d3fcob1: 3fco B:24-289 [175689]
  Other proteins in same PDB: d3fcoa2, d3fcob2
  automated match to d1xu9a_
  complexed with iig, nap
Domain(s) for 3frj:
1. Domain d3frja1: 3frj A:24-284 [176002]
  Other proteins in same PDB: d3frja2, d3frjb2
  automated match to d1xu9a_
  complexed with a49, nap
2. Domain d3frjb1: 3frj B:24-284 [176003]
  Other proteins in same PDB: d3frja2, d3frjb2
  automated match to d1xu9a_
  complexed with a49, nap
Domain(s) for 3h6k:
1. Domain d3h6ka_: 3h6k A: [177284]
  Other proteins in same PDB: d3h6kb2
  automated match to d1xu9a_
  complexed with 33t, nap
2. Domain d3h6kb1: 3h6k B:24-282 [177285]
  Other proteins in same PDB: d3h6kb2
  automated match to d1xu9a_
  complexed with 33t, nap
3. Domain d3h6kc_: 3h6k C: [177286]
  Other proteins in same PDB: d3h6kb2
  automated match to d1xu9a_
  complexed with 33t, nap
4. Domain d3h6kd_: 3h6k D: [177287]
  Other proteins in same PDB: d3h6kb2
  automated match to d1xu9a_
  complexed with 33t, nap
Domain(s) for 3hfg:
1. Domain d3hfga_: 3hfg A: [177530]
  Other proteins in same PDB: d3hfgb2
  automated match to d1xu9a_
  complexed with 17r, nap
2. Domain d3hfgb1: 3hfg B:24-282 [177531]
  Other proteins in same PDB: d3hfgb2
  automated match to d1xu9a_
  complexed with 17r, nap
3. Domain d3hfgc_: 3hfg C: [177532]
  Other proteins in same PDB: d3hfgb2
  automated match to d1xu9a_
  complexed with 17r, nap
4. Domain d3hfgd_: 3hfg D: [177533]
  Other proteins in same PDB: d3hfgb2
  automated match to d1xu9a_
  complexed with 17r, nap
Domain(s) for 3oq1:
1. Domain d3oq1a1: 3oq1 A:24-281 [214474]
  Other proteins in same PDB: d3oq1a2, d3oq1b2, d3oq1c2, d3oq1d2
  automated match to d1xu9a_
  complexed with 3oq, nap
2. Domain d3oq1b1: 3oq1 B:24-287 [214475]
  Other proteins in same PDB: d3oq1a2, d3oq1b2, d3oq1c2, d3oq1d2
  automated match to d1xu9a_
  complexed with 3oq, nap
3. Domain d3oq1c1: 3oq1 C:24-289 [214476]
  Other proteins in same PDB: d3oq1a2, d3oq1b2, d3oq1c2, d3oq1d2
  automated match to d1xu9a_
  complexed with 3oq, nap
4. Domain d3oq1d1: 3oq1 D:24-281 [214477]
  Other proteins in same PDB: d3oq1a2, d3oq1b2, d3oq1c2, d3oq1d2
  automated match to d1xu9a_
  complexed with 3oq, nap
Domain(s) for 3pdj:
1. Domain d3pdja1: 3pdj A:24-291 [183673]
  Other proteins in same PDB: d3pdja2, d3pdjb2
  automated match to d1xu9b_
  complexed with 3pj, nap
2. Domain d3pdjb1: 3pdj B:24-292 [183674]
  Other proteins in same PDB: d3pdja2, d3pdjb2
  automated match to d1xu9b_
  complexed with 3pj, nap
Domain(s) for 3qqp:
1. Domain d3qqpa1: 3qqp A:24-289 [215369]
  Other proteins in same PDB: d3qqpa2, d3qqpb2, d3qqpc2, d3qqpd2
  automated match to d1xu9b_
  complexed with ndp, s05
2. Domain d3qqpb1: 3qqp B:24-285 [215370]
  Other proteins in same PDB: d3qqpa2, d3qqpb2, d3qqpc2, d3qqpd2
  automated match to d1xu9b_
  complexed with ndp, s05
3. Domain d3qqpc1: 3qqp C:24-281 [215371]
  Other proteins in same PDB: d3qqpa2, d3qqpb2, d3qqpc2, d3qqpd2
  automated match to d1xu9b_
  complexed with ndp, s05
4. Domain d3qqpd1: 3qqp D:24-277 [215372]
  Other proteins in same PDB: d3qqpa2, d3qqpb2, d3qqpc2, d3qqpd2
  automated match to d1xu9b_
  complexed with ndp, s05
Domain(s) for 3tfq:
1. Domain d3tfqa_: 3tfq A: [185814]
  Other proteins in same PDB: d3tfqb2, d3tfqd2
  automated match to d1xu9a_
  complexed with 07m, gol, nap; mutant
2. Domain d3tfqb1: 3tfq B:24-290 [185815]
  Other proteins in same PDB: d3tfqb2, d3tfqd2
  automated match to d1xu9a_
  complexed with 07m, gol, nap; mutant
3. Domain d3tfqd1: 3tfq D:24-284 [185816]
  Other proteins in same PDB: d3tfqb2, d3tfqd2
  automated match to d1xu9a_
  complexed with 07m, gol, nap; mutant
4. Domain d3tfqe_: 3tfq E: [185817]
  Other proteins in same PDB: d3tfqb2, d3tfqd2
  automated match to d1xu9a_
  complexed with 07m, gol, nap; mutant
Domain(s) for 4hfr:
1. Domain d4hfra_: 4hfr A: [222558]
  automated match to d3pdjb_
  complexed with 14m, nap
2. Domain d4hfrb_: 4hfr B: [222559]
  automated match to d3pdjb_
  complexed with 14m, nap
Domain(s) for 4hx5:
1. Domain d4hx5a_: 4hx5 A: [197024]
  Other proteins in same PDB: d4hx5b2, d4hx5c2, d4hx5d2
  automated match to d3pdjb_
  complexed with 19v, ndp
2. Domain d4hx5b1: 4hx5 B:24-283 [197314]
  Other proteins in same PDB: d4hx5b2, d4hx5c2, d4hx5d2
  automated match to d3pdjb_
  complexed with 19v, ndp
3. Domain d4hx5c1: 4hx5 C:24-284 [197313]
  Other proteins in same PDB: d4hx5b2, d4hx5c2, d4hx5d2
  automated match to d3pdjb_
  complexed with 19v, ndp
4. Domain d4hx5d1: 4hx5 D:24-279 [202508]
  Other proteins in same PDB: d4hx5b2, d4hx5c2, d4hx5d2
  automated match to d1xu9b_
  complexed with 19v, ndp
Domain(s) for 4iju:
1. Domain d4ijua_: 4iju A: [256781]
  Other proteins in same PDB: d4ijub2, d4ijud2
  automated match to d3tfqb_
  complexed with 1eo, cl, nap; mutant
2. Domain d4ijub1: 4iju B:11-291 [262723]
  Other proteins in same PDB: d4ijub2, d4ijud2
  automated match to d3tfqb_
  complexed with 1eo, cl, nap; mutant
3. Domain d4ijud1: 4iju D:11-284 [258662]
  Other proteins in same PDB: d4ijub2, d4ijud2
  automated match to d3tfqb_
  complexed with 1eo, cl, nap; mutant
4. Domain d4ijue_: 4iju E: [262724]
  Other proteins in same PDB: d4ijub2, d4ijud2
  automated match to d3tfqb_
  complexed with 1eo, cl, nap; mutant
Domain(s) for 4ijv:
1. Domain d4ijva_: 4ijv A: [266432]
  Other proteins in same PDB: d4ijvb2, d4ijvd2
  automated match to d3tfqb_
  complexed with 1en, nap; mutant
2. Domain d4ijvb1: 4ijv B:11-290 [266433]
  Other proteins in same PDB: d4ijvb2, d4ijvd2
  automated match to d3tfqb_
  complexed with 1en, nap; mutant
3. Domain d4ijvd1: 4ijv D:11-284 [266434]
  Other proteins in same PDB: d4ijvb2, d4ijvd2
  automated match to d3tfqb_
  complexed with 1en, nap; mutant
4. Domain d4ijve_: 4ijv E: [266435]
  Other proteins in same PDB: d4ijvb2, d4ijvd2
  automated match to d3tfqb_
  complexed with 1en, nap; mutant
Domain(s) for 4ijw:
1. Domain d4ijwa_: 4ijw A: [266436]
  Other proteins in same PDB: d4ijwb2, d4ijwd2
  automated match to d3tfqb_
  complexed with 1eq, nap; mutant
2. Domain d4ijwb1: 4ijw B:11-288 [266437]
  Other proteins in same PDB: d4ijwb2, d4ijwd2
  automated match to d3tfqb_
  complexed with 1eq, nap; mutant
3. Domain d4ijwd1: 4ijw D:11-284 [266438]
  Other proteins in same PDB: d4ijwb2, d4ijwd2
  automated match to d3tfqb_
  complexed with 1eq, nap; mutant
4. Domain d4ijwe_: 4ijw E: [266439]
  Other proteins in same PDB: d4ijwb2, d4ijwd2
  automated match to d3tfqb_
  complexed with 1eq, nap; mutant
Domain(s) for 4k1l:
1. Domain d4k1la1: 4k1l A:24-283 [238381]
  Other proteins in same PDB: d4k1la2, d4k1lb2, d4k1lc2, d4k1ld2
  automated match to d1xu9a_
  complexed with ndp, sff
2. Domain d4k1lb1: 4k1l B:24-285 [238387]
  Other proteins in same PDB: d4k1la2, d4k1lb2, d4k1lc2, d4k1ld2
  automated match to d1xu9b_
  complexed with ndp, sff
3. Domain d4k1lc1: 4k1l C:24-289 [238389]
  Other proteins in same PDB: d4k1la2, d4k1lb2, d4k1lc2, d4k1ld2
  automated match to d1xu9a_
  complexed with ndp, sff
4. Domain d4k1ld1: 4k1l D:24-283 [238390]
  Other proteins in same PDB: d4k1la2, d4k1lb2, d4k1lc2, d4k1ld2
  automated match to d1xu9b_
  complexed with ndp, sff
Domain(s) for 4p38:
1. Domain d4p38a_: 4p38 A: [257395]
  automated match to d4bb6a_
  complexed with 21t, cl, ndp
2. Domain d4p38b_: 4p38 B: [260937]
  automated match to d4bb6a_
  complexed with 21t, cl, ndp

More info for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1:

Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1 first appeared in SCOP 1.71
Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1 appears in SCOPe 2.05
Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1 appears in SCOPe 2.07
Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1 appears in the current release, SCOPe 2.08